Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15196329 | 0.89 | ALDH1A1 (0.39) | HSD17B10POLBALDH1A1SMN1; SMN2CA2 | |
| SCHEMBL9072457 | 0.89 | CYP1A2 (0.40) | ALDH1A1CA2CA4CA12CA1 | |
| SCHEMBL16488510 | 0.77 | CXCR1 (0.38) | HSD17B10POLBALDH1A1CXCR1CXCR2 | |
| SCHEMBL2668579 | 0.76 | ATM (0.39) | ALDH1A1HPGDLMNAMEN1RAB9A | |
| SCHEMBL10588609 | 0.71 | LMNA (0.47) | HSD17B10POLBALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL2667557 | 0.70 | ATM (0.39) | HSD17B10ALDH1A1CXCR1CXCR2HPGD | |
| SCHEMBL8144828 | 0.70 | HSD17B10 (0.66) | HSD17B10POLBALDH1A1MAPK1GAA | |
| SCHEMBL9072456 | 0.70 | CXCR1 (0.45) | SMN1; SMN2CXCR1CXCR2RAB9AMAPT | |
| SCHEMBL17045927 | 0.69 | EPHX2 (0.52) | HSD17B10POLBALDH1A1LMNAMEN1 | |
| SCHEMBL28897181 | 0.69 | CYP1A2 (0.59) | POLBALDH1A1SMN1; SMN2MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543667-B1 | A method of preparing 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC (US) | 2015-01-28 | — | — | EP | disclosed |