Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4677113 | 0.83 | SMN1; SMN2 (0.54) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL27770163 | 0.80 | MEN1 (0.47) | KMT2AMEN1AKR1B1PDPK1 | |
| SCHEMBL28355512 | 0.78 | MGLL (0.52) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL20975507 | 0.77 | POLB (0.63) | NPC1RAB9ALMNASMN1; SMN2KMT2A | |
| SCHEMBL26697159 | 0.77 | RAB9A (0.62) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL8061206 | 0.76 | KCNA5 (0.60) | NPC1LMNASMN1; SMN2ALDH1A1AKR1B1 | |
| SCHEMBL13034145 | 0.75 | MEN1 (0.53) | ALDH1A1KMT2AMEN1AKR1B1PDPK1 | |
| SCHEMBL29707309 | 0.74 | LMNA (0.52) | NPC1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL19210898 | 0.74 | LMNA (0.52) | NPC1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL28359298 | 0.74 | LMNA (0.50) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023226580-A1 | PYRROLOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 中国医学科学院药物研究所 | 2023-11-30 | — | — | WO | disclosed |