SCHEMBL2675178

SCHEMBL2675178

O=C1CCc2c(Br)cc(Br)cc2C1

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.38
HSP90AA1 P07900 1/20 0.34
TLR9 Q9NR96 1/20 0.34
METAP1 P53582 1/20 0.34
PARP10 Q53GL7 2/20 0.33
TDP2 O95551 1/20 0.33
PARP11 Q9NR21 1/20 0.33
CMA1 P23946 1/20 0.32
AHR P35869 1/20 0.32
SRD5A1 P18405 1/20 0.31
TDP1 Q9NUW8 2/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
CYP3A4 P08684 1/20 0.30
TSHR P16473 1/20 0.30
PARP1 P09874 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2676588 0.84 CYP2A6 (0.38) CYP2A6HSP90AA1TLR9METAP1PARP10
SCHEMBL30748444 0.81 CYP2A6 (0.35) CYP2A6CMA1AHR
SCHEMBL415637 0.73 CYP2A6 (0.54) CYP2A6METAP1PARP10TDP2PARP11
SCHEMBL354022 0.73 CYP2A6 (0.54) CYP2A6METAP1PARP10TDP2PARP11
SCHEMBL1662187 0.72 CYP2A6 (0.52) CYP2A6PARP10PARP11TDP1L3MBTL1
SCHEMBL29385577 0.72 CYP2A6 (0.52) CYP2A6PARP10PARP11TDP1L3MBTL1
Ethylene SCHEMBL5830934 0.71 CYP2A6 (0.50) CYP2A6METAP1PARP10TDP2PARP11
SCHEMBL20722582 0.69 CYP2A6 (0.35) CYP2A6PARP10TDP2PARP11CMA1
SCHEMBL2869448 0.68 CYP2A6 (0.42) CYP2A6CYP3A4
SCHEMBL22534296 0.68 NMT1 (0.35) METAP1TDP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119410365-A Bromine-doped carbon dot and nano micelle assembly thereof, preparation method and application 四川大学 2025-02-11 CN claimed
CN-119410365-A Bromine-doped carbon dot and nano micelle assembly thereof, preparation method and application 四川大学 2025-02-11 CN disclosed
CN-118056821-A Compound, organic photodetector including compound, and electronic device 三星显示有限公司 2024-05-21 CN disclosed
CN-117529325-A Improved process for preparing 7- (morpholinyl) -2- (N-piperazinyl) methylthio [2,3-c ] pyridine derivatives 纳特科药品有限公司 2024-02-06 CN disclosed
CN-110392938-B Polar elastomer microstructures and methods of making the same 康宁股份有限公司 2023-11-14 CN disclosed
CN-115974872-A Aza-and-ring derivatives, pharmaceutical compositions thereof and uses thereof 南方科技大学 2023-04-18 CN disclosed
CN-111808068-B Tetraphenyl ethylene functionalized oligopolymerization thiophene derivative, preparation method and application thereof 南京信息工程大学 2023-04-07 CN disclosed
CN-114466897-A Resin composition, film, composite material, moving body, and material for three-dimensional modeling 三菱化学株式会社 2022-05-10 CN disclosed
US-8173696-B2 Inhibitors of cysteine proteases and methods of use thereof BAYLOR UNIVERSITY (US) 2012-05-08 US disclosed
US-20090076076-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF BAYLOR UNIVERSITY (US) 2009-03-19 US disclosed
EP-0517876-B1 THERAPEUTIC BENZAZEPINE COMPOUNDS ZENECA LTD (GB) 1996-10-23 EP disclosed
US-5541319-A REACTING SUBSTITUTED BENZAZEPINE ETHER WITH BORON TRIHALIDE TO FORM HYDROXY GROUP, FORMING SALT WITH BASE IF DESIRED ZENECA LIMITED (GB) 1996-07-30 US disclosed
US-5446039-A Treating nervous system and brain disorder, acting as excitatory amino acid antagonist IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) 1995-08-29 US disclosed
US-5254683-A Neurological disorders IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-10-19 US disclosed
EP-0517876-A1 THERAPEUTIC BENZAZEPINE COMPOUNDS. ICI PLC (GB) 1992-12-16 EP disclosed
WO-1992011854-A1 THERAPEUTIC BENZAZEPINE COMPOUNDS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1992-07-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090076076-A1 INHIBITORS OF CYSTEINE PROTEASES AND METHODS OF USE THEREOF CTSB, CTSS, CTSZ CYP2A6 2423/4885HSP90AA1 998/4885TLR9 4385/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.