Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3664702 | 0.83 | P2RX7 (0.46) | P2RX7KDM4ESMN1; SMN2HTTTDP1 | |
| SCHEMBL26791951 | 0.81 | KDM4E (0.51) | TRPM8KDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL26795701 | 0.80 | P2RX7 (0.42) | P2RX7TRPM8KDM4ESMN1; SMN2HTT | |
| SCHEMBL26791923 | 0.77 | TRPM8 (0.38) | P2RX7TRPM8KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL3666287 | 0.77 | KDM4E (0.53) | TRPM8KDM4EMAPTKMT2AALDH1A1 | |
| SCHEMBL13043130 | 0.67 | KDM4E (0.69) | KDM4ESMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL4497703 | 0.67 | SMN1; SMN2 (0.59) | TRPM8KDM4ESMN1; SMN2MAPTKMT2A | |
| SCHEMBL26797730 | 0.66 | ALDH1A1 (0.68) | KDM4ESMN1; SMN2KMT2AALDH1A1HPGD | |
| SCHEMBL31412312 | 0.65 | LMNA (0.58) | KDM4ESMN1; SMN2MAPTKMT2AALDH1A1 | |
| SCHEMBL20646835 | 0.65 | KDM4E (0.72) | KDM4ESMN1; SMN2MAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365531-A1 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMO VIRUS | MERCK SHARP & DOHME LLC (US) | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365531-A1 | INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMO VIRUS | METAP1, SARS1, RTF1 | P2RX7 4243/4885TRPM8 3249/4885KDM4E 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.