Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | USP14 | P54578 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26661831 | 0.87 | SIGMAR1 (0.58) | SIGMAR1KCNA3L3MBTL1DRD2CCR5 | |
| SCHEMBL8257331 | 0.87 | KCNA3 (0.56) | SIGMAR1KCNA3L3MBTL1DRD2CCR5 | |
| SCHEMBL30401098 | 0.84 | KCNA3 (0.55) | SIGMAR1KCNA3L3MBTL1DRD2CCR5 | |
| SCHEMBL22928915 | 0.83 | KCNA3 (0.66) | SIGMAR1KCNA3L3MBTL1DRD2CCR5 | |
| SCHEMBL15297748 | 0.81 | KCNA3 (0.54) | KCNA3DRD2CCR5DRD3MEN1 | |
| SCHEMBL27889136 | 0.80 | KCNA3 (0.55) | SIGMAR1KCNA3L3MBTL1DRD2CCR5 | |
| SCHEMBL14119467 | 0.79 | CKS1B (0.46) | KCNA3L3MBTL1DRD2DRD3KMT2A | |
| SCHEMBL19091691 | 0.78 | KDM1A (0.59) | SIGMAR1KCNA3 | |
| SCHEMBL7724023 | 0.78 | KCNA3 (0.49) | KCNA3DRD2DRD3 | |
| SCHEMBL7724014 | 0.78 | KCNA3 (0.49) | KCNA3DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11833208-B2 | PLK1 selective degradation inducing compound | UPPTHERA, INC. (KR) | 2023-12-05 | — | — | US | disclosed |
| US-11833208-B2 | PLK1 selective degradation inducing compound | UPPTHERA, INC. (KR) | 2023-12-05 | — | — | US | disclosed |
| US-20230372498-A1 | PLK1 SELECTIVE DEGRADATION INDUCING COMPOUND | UPPTHERA (KR) | 2023-11-23 | — | — | US | disclosed |
| US-20230372498-A1 | PLK1 SELECTIVE DEGRADATION INDUCING COMPOUND | UPPTHERA (KR) | 2023-11-23 | — | — | US | disclosed |
| CN-113784969-A | PLK1 Selective degradation inducing Compounds | 厄普特拉公司 | 2021-12-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230372498-A1 | PLK1 SELECTIVE DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | SIGMAR1 4807/4885KCNA3 3663/4885L3MBTL1 719/4885 |
| US-11833208-B2 | PLK1 selective degradation inducing compound | PLK1, BUB1B, BUB1 | SIGMAR1 4807/4885KCNA3 3663/4885L3MBTL1 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.