Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 5/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | USP14 | P54578 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30401098 | 0.89 | KCNA3 (0.55) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 | |
| SCHEMBL22928915 | 0.89 | KCNA3 (0.66) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 | |
| SCHEMBL26661831 | 0.88 | SIGMAR1 (0.58) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 | |
| SCHEMBL26813618 | 0.87 | SIGMAR1 (0.51) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 | |
| SCHEMBL27889136 | 0.84 | KCNA3 (0.55) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 | |
| SCHEMBL7724023 | 0.84 | KCNA3 (0.49) | KCNA3DRD2HRH1DRD3DRD4 | |
| SCHEMBL7724014 | 0.84 | KCNA3 (0.49) | KCNA3DRD2HRH1DRD3DRD4 | |
| SCHEMBL4305546 | 0.83 | L3MBTL1 (0.64) | L3MBTL1SIGMAR1CA12CA1CA2 | |
| SCHEMBL7724060 | 0.83 | KCNA3 (0.59) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 | |
| SCHEMBL7724067 | 0.83 | KCNA3 (0.59) | KCNA3L3MBTL1SIGMAR1DRD2CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090124600-A1 | N-Alkyl-Azacycloalkyl NMDA/NR2B Antagonists | MERCK SHARP & DOHME CORP. | 2009-05-14 | — | — | US | disclosed |
| WO-2006113471-A2 | N-ALKYL-AZACYCLOALKYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124600-A1 | N-Alkyl-Azacycloalkyl NMDA/NR2B Antagonists | GRIN2B, GRIN2A, GRIN1 | KCNA3 231/4885L3MBTL1 2478/4885SIGMAR1 554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.