SCHEMBL26836233

SCHEMBL26836233

O=C1CC2CC(O)CC(C1)c1c(F)cccc12

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.47
CHRNA4 P43681 3/20 0.47
TRPV1 Q8NER1 4/20 0.35
KDM1A O60341 2/20 0.35
KDM1B Q8NB78 1/20 0.35
AADAT Q8N5Z0 2/20 0.34
CHRNA7 P36544 1/20 0.34
LDHA P00338 2/20 0.33
LDHB P07195 2/20 0.33
TP53 P04637 1/20 0.33
RECQL P46063 1/20 0.33
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
HTR2C P28335 2/20 0.32
HTR2B P41595 2/20 0.32
ABCB1 P08183 1/20 0.32
PIM1 P11309 2/20 0.31
PIM3 Q86V86 2/20 0.31
PIM2 Q9P1W9 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21606744 0.83 CHRNB2 (0.51) CHRNB2CHRNA4KDM1AKDM1BAADAT
SCHEMBL30665167 0.83 CHRNB2 (0.51) CHRNB2CHRNA4KDM1AKDM1BAADAT
SCHEMBL425268 0.75 LDHA (0.43) CHRNB2CHRNA4AADATLDHALDHB
SCHEMBL31389997 0.75 CHRNB2 (0.44) CHRNB2CHRNA4KDM1AKDM1BCHRNA7
SCHEMBL428500 0.71 TP53 (0.43) CHRNB2CHRNA4KDM1AKDM1BAADAT
SCHEMBL425265 0.70 KDM1A (0.50) KDM1AKDM1BTP53RECQLHTR2C
SCHEMBL31389850 0.70 KDM1A (0.50) CHRNB2CHRNA4TRPV1KDM1AKDM1B
SCHEMBL18625858 0.69 MTNR1A (0.51) KDM1A
SCHEMBL25047082 0.69 CHRNB2 (0.65) CHRNB2CHRNA4KDM1AKDM1BCHRNA7
SCHEMBL30851861 0.68 ACHE (0.40) CHRNB2CHRNA4AADATLDHALDHB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3810572-B1 POLYCYCLIC COMPOUNDS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS UNIV BARCELONA (ES) 2023-11-15 EP disclosed