SCHEMBL2684480

SCHEMBL2684480

Cl[SiH2]CCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
HPGD P15428 1/20 0.48
ALOX15 P16050 1/20 0.48
ALOX12 P18054 1/20 0.48
CASP1 P29466 1/20 0.48
HSD17B10 Q99714 1/20 0.48
TAAR1 Q96RJ0 3/20 0.46
TDP1 Q9NUW8 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
CYP2A6 P11509 1/20 0.46
HTR2A P28223 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.46
MAOA P21397 4/20 0.42
MAOB P27338 4/20 0.42
CALM1 P0DP23 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
ATM Q13315 1/20 0.41
KEAP1 Q14145 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloromethane SCHEMBL29048090 0.95 ALDH1A1 (0.44) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8718870 0.86 GFER (0.36) ALDH1A1TAAR1CYP2A6HTR2AMAOA
SCHEMBL2272071 0.85 SIGMAR1 (0.48) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL11457819 0.80 ALDH1A1 (0.55) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8382309 0.78 ALDH1A1 (0.52) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8718872 0.76 TAAR1 (0.37) TAAR1HTR2AIDO1SLC6A2AOC3
Hydrochloric Acid SCHEMBL1030795 0.76 ALDH1A1 (0.50) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8997247 0.75 ALDH1A1 (0.44) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL11055920 0.74 TDP1 (0.52) ALDH1A1HPGDALOX15ALOX12CASP1
SCHEMBL8384814 0.74 ALDH1A1 (0.48) ALDH1A1HPGDALOX15ALOX12CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0540084-B1 Method for passivating the inner surface of a reactor subject to coking, by deposition of a ceramic coating, and method of pyrolyzing hydrocarbons ENICHEM SPA (IT) 1996-09-04 EP claimed
EP-0540084-A1 Method for passivating the inner surface of a reactor subject to coking, by deposition of a ceramic coating, and method of pyrolyzing hydrocarbons ENICHEM S.p.A. (IT) 1993-05-05 EP claimed
US-5208069-A Silane precursor ISTITUTO GUIDO DONEGANI S.P.A. (IT) 1993-05-04 US claimed
US-5017636-A Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-21 US claimed
EP-0136429-B1 PROCESS FOR THE PREPARATION OF 2-PHENYLETHYLCHLORSILANES HÜLS AKTIENGESELLSCHAFT (DE) 1989-01-25 EP claimed
US-4537983-A HYDROGEN CHLOROSILANES ARE REACTED WITH STYRENE IN THE PRESENCE OFF BENZOTHZAZOLE AND A PLATIUM CATALYST DYNAMIT NOBEL AG (DE) 1985-08-27 US claimed
US-4417069-A FROM STYRENE AND CHLOROSILANE, PLATINUM CATALYST AND TERTIARY AMINE GENERAL ELECTRIC COMPANY (US) 1983-11-22 US claimed
CN-119350383-A Preparation method of phenethyl trialkoxysilane 辽宁盖尔化工有限公司 2025-01-24 CN disclosed
CN-102498117-A Organic Chlorosilane And Method For Preparing Same SAMSUNG FINE CHEMICALS CO LTD 2012-06-13 CN disclosed
US-20120114544-A1 ORGANIC CHLOROHYDROSILANE AND METHOD FOR PREPARING THEM SAMSUNG FINE CHEMICALS CO., LTD (KR) 2012-05-10 US disclosed
US-8084608-B2 2,2′ -bipyridine derivative having a reactive silyl group, its production method, and transition metal complex SHIN-ETSU CHEMICAL CO., LTD. (JP) 2011-12-27 US disclosed
US-20090299068-A1 2,2' -BIPYRIDINE DERIVATIVE HAVING A REACTIVE SILYL GROUP, ITS PRODUCTION METHOD, AND TRANSITION METAL COMPLEX SHIN-ETSU CHEMICAL CO., LTD. (JP) 2009-12-03 US disclosed
EP-2128165-A1 2, 2´-bipyridine derivatives having reactive silyl group, production methods, transition metal complexes thereof Shin-Etsu Chemical Co., Ltd. (JP) 2009-12-02 EP disclosed
EP-0136429-A2 Process for the preparation of 2-phenylethylchlorsilanes HÜLS AKTIENGESELLSCHAFT (DE) 1985-04-10 EP disclosed
EP-0136429-A2 Process for the preparation of 2-phenylethylchlorsilanes HÜLS AKTIENGESELLSCHAFT (DE) 1985-04-10 EP disclosed
US-4476291-A Resins containing β-phenylethyl trifunctional siloxy units and method for making GENERAL ELECTRIC COMPANY (US) 1984-10-09 US disclosed
US-4417069-A FROM STYRENE AND CHLOROSILANE, PLATINUM CATALYST AND TERTIARY AMINE GENERAL ELECTRIC COMPANY (US) 1983-11-22 US disclosed
US-4417069-A FROM STYRENE AND CHLOROSILANE, PLATINUM CATALYST AND TERTIARY AMINE GENERAL ELECTRIC COMPANY (US) 1983-11-22 US disclosed
US-4417069-A FROM STYRENE AND CHLOROSILANE, PLATINUM CATALYST AND TERTIARY AMINE GENERAL ELECTRIC COMPANY (US) 1983-11-22 US disclosed
EP-0000614-B1 PRODUCTION OF DICHLOROSILANE DERIVATIVES Chisso Corporation (JP) 1981-11-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120114544-A1 ORGANIC CHLOROHYDROSILANE AND METHOD FOR PREPARING THEM PHPT1, SIK1, SIK2 ALDH1A1 4436/4885HPGD 4055/4885ALOX15 3854/4885
US-20090299068-A1 2,2' -BIPYRIDINE DERIVATIVE HAVING A REACTIVE SILYL GROUP, ITS PRODUCTION METHOD, AND TRANSITION METAL COMPLEX CBR3, TST, HRH3 ALDH1A1 2668/4885HPGD 2325/4885ALOX15 3381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.