Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26847491 | 0.71 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4APOBEC3G | |
| SCHEMBL12090641 | 0.70 | PTGS2 (0.51) | ALDH1A1SMN1; SMN2PTGS1TDP1PTGS2 | |
| SCHEMBL21233174 | 0.70 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4APOBEC3G | |
| SCHEMBL14091695 | 0.69 | NPC1 (0.54) | ALDH1A1SMN1; SMN2POLBMAPTHPGD | |
| SCHEMBL26847544 | 0.67 | CHRNA1 (0.36) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4TDP1 | |
| SCHEMBL21233177 | 0.67 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4APOBEC3G | |
| SCHEMBL21233330 | 0.67 | LMNA (0.42) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4APOBEC3G | |
| SCHEMBL14996583 | 0.67 | HSD11B1 (0.50) | ALDH1A1SMN1; SMN2CYP1A2MAPTHPGD | |
| SCHEMBL26847441 | 0.66 | DRD2 (0.36) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4POLB | |
| SCHEMBL14996550 | 0.66 | HSD11B1 (0.54) | ALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | NOVARTIS AG (CH) | 2023-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365571-A1 | COMPOUNDS AND COMPOSITIONS AS Sppl2a INHIBITORS | SPPL2A, SPPL2B, BACE1 | RORC 3545/4885ALDH1A1 3565/4885SMN1; SMN2 2626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.