Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.32 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.32 |
| ▸ | HTR5A | P47898 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3218102 | 0.88 | PRKAB2 (0.34) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL3213753 | 0.88 | PRKAB2 (0.34) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL3218165 | 0.88 | PRKAB2 (0.34) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL3216852 | 0.87 | PKM (0.35) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL3222181 | 0.87 | PKM (0.35) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL3211615 | 0.87 | PKM (0.35) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL2686648 | 0.84 | PRKAB2 (0.39) | HTR2AHTR2CHTR2BCASRHTR1A | |
| SCHEMBL2684325 | 0.83 | CA2 (0.39) | HTR2AHTR2CHTR2BCASRHTR1A | |
| SCHEMBL3208813 | 0.82 | HTR2C (0.36) | BRD4CREBBPHTR2AHTR2CHTR2B | |
| SCHEMBL3209728 | 0.82 | HTR2C (0.36) | BRD4CREBBPHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438050-B9 | NOVEL DERIVATIVES OF ARYL-{4-HALOGENO-4-[AMINOMETHYL]-PIPERIDIN-1-YL}-METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | PF MEDICAMENT (FR) | 2014-04-23 | — | — | EP | disclosed |
| US-8669250-B2 | Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products | PIERRE FABRE MEDICAMENT (FR) | 2014-03-11 | — | — | US | disclosed |
| EP-2438050-B1 | NOVEL DERIVATIVES OF ARYL-{4-HALOGENO-4-[AMINOMETHYL]-PIPERIDIN-1-YL}-METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | PF MEDICAMENT (FR) | 2013-08-07 | — | — | EP | disclosed |
| US-20120115860-A1 | NOVEL DERIVATIVES OF ARYL--METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | PIERRE FABRE MEDICAMENT (FR) | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120115860-A1 | NOVEL DERIVATIVES OF ARYL--METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS | CYP11B1, CYP11B2, CYP3A43 | BRD4 1520/4885CREBBP 2187/4885HTR2A 1459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.