SCHEMBL2689135

SCHEMBL2689135

CCCOCC1(C(=O)c2ccccc2)c2ccccc2-c2ccccc21

nearest known ligand 0.44

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.44
THRB P10828 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
MTTP P55157 1/20 0.36
APEX1 P27695 1/20 0.36
KMT2A Q03164 2/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.36
RAB9A P51151 1/20 0.36
PDK2 Q15119 2/20 0.36
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2687866 0.92 MTTP (0.42) LMNAMTTPMAPTPDK2
SCHEMBL2687240 0.91 CYP2C9 (0.41) TDP1MTTPKMT2AMAPK1PDK2
SCHEMBL2688828 0.88 THRB (0.39) LMNATHRBTDP1APEX1KMT2A
SCHEMBL2686305 0.84 PDK2 (0.38) LMNATHRBTDP1MTTPAPEX1
SCHEMBL2687643 0.82 PDK2 (0.37) LMNATHRBTDP1MTTPAPEX1
SCHEMBL2689178 0.82 MAPT (0.42) LMNATHRBTDP1APEX1KMT2A
SCHEMBL2687261 0.81 APEX1 (0.37) LMNAMTTPAPEX1NPC1RAB9A
SCHEMBL16035090 0.81 ALDH1A1 (0.39) LMNAMTTPMAPTPDK2HSD17B10
SCHEMBL2685785 0.79 MTTP (0.38) MTTPAPEX1PDK2
SCHEMBL2686863 0.78 SOAT1 (0.39) MTTPMAPK1PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3118226-A1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF Corporation (US) 2017-01-18 EP claimed
EP-2782938-B1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF CORP (US) 2016-08-31 EP claimed
CN-102834420-B Internal and external donor compounds for olefin polymerization catalysts ii BASF CORP. (US) 2014-10-22 CN claimed
EP-2782938-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF Corporation (US) 2014-10-01 EP claimed
WO-2013077837-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF CORPORATION (US) 2013-05-30 WO claimed
US-8227370-B2 High activity catalyst component for olefin polymerization and method of using the same BASF CORPORATION (US) 2012-07-24 US claimed
CN-102574954-A Internal donor for olefin polymerization catalysts BASF CATALYSTS LLC 2012-07-11 CN claimed
US-20120116031-A1 High Activity Catalyst Component for Olefin Polymerization and Method of Using the Same BASF CORPORATION (US) 2012-05-10 US claimed
CN-107207657-B Process for preparing spherical polymerization catalyst components for olefin polymerization 格雷斯公司 2020-03-03 CN disclosed
EP-3118226-A1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF Corporation (US) 2017-01-18 EP disclosed
EP-2782938-B1 HIGH ACTIVITY CATALYST FOR OLEFIN POLYMERIZATION BASF CORP (US) 2016-08-31 EP disclosed
CN-102574954-B Internal donor for olefin polymerization catalysts BASF SE 2014-11-19 CN disclosed
CN-102834420-B Internal and external donor compounds for olefin polymerization catalysts ii BASF CORP. (US) 2014-10-22 CN disclosed
EP-2782938-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF Corporation (US) 2014-10-01 EP disclosed
CN-104053682-A High activity catalyst component for olefin polymerization and method of using the same BASF SE 2014-09-17 CN disclosed
WO-2013077837-A1 HIGH ACTIVITY CATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND METHOD OF USING THE SAME BASF CORPORATION (US) 2013-05-30 WO disclosed
CN-102656194-A Mixed donor system for high melt flow and high activity BASF CORP 2012-09-05 CN disclosed
US-8227370-B2 High activity catalyst component for olefin polymerization and method of using the same BASF CORPORATION (US) 2012-07-24 US disclosed
CN-102574954-A Internal donor for olefin polymerization catalysts BASF CATALYSTS LLC 2012-07-11 CN disclosed
US-20120116031-A1 High Activity Catalyst Component for Olefin Polymerization and Method of Using the Same BASF CORPORATION (US) 2012-05-10 US disclosed