SCHEMBL2689756

SCHEMBL2689756

CC(=O)Nc1ccc(OC[C@](C)(O)C(=O)Nc2ccc([N+](=O)[O-])c(C(F)(F)F)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29359806 1.00 AR (1.00) AR
SCHEMBL16871452 1.00 AR (1.00) AR
SCHEMBL2450766 1.00 AR (1.00) AR
SCHEMBL14522362 0.92 AR (0.85) AR
SCHEMBL607245 0.91 AR (0.84) AR
SCHEMBL607246 0.91 AR (0.84) AR
SCHEMBL3698441 0.91 AR (1.00) AR
SCHEMBL2746561 0.91 AR (1.00) AR
SCHEMBL14252926 0.91 AR (0.85) AR
SCHEMBL12706742 0.91 AR (0.85) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2276496-B1 THERAPEUTIC MODULATION OF OCULAR SURFACE LUBRICATION UNIV CALIFORNIA (US) 2019-07-10 EP claimed
US-9421241-B2 Therapeutic modulation of ocular surface lubrication THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-08-23 US claimed
US-20160015780-A1 Therapeutic Modulation of Ocular Surface Lubrication THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2016-01-21 US claimed
US-9138457-B2 Therapeutic modulation of ocular surface lubrication THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2015-09-22 US claimed
WO-2009137602-A1 THERAPEUTIC MODULATION OF OCULAR SURFACE LUBRICATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2009-11-12 WO claimed
US-20230172897-A1 METHODS OF TREATING BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS AND ADDITIONAL THERAPEUTIC AGENTS VERU, INC. (US) 2023-06-08 US disclosed
US-20210254056-A1 IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS CAMP4 THERAPEUTICS CORPORATION 2021-08-19 US disclosed
US-20210228529-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING BREAST CANCERS AND METHODS OF USES THEREOF UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2021-07-29 US disclosed
US-20210128513-A1 NON-INVASIVE METHOD OF EVALUATING BREAST CANCERS FOR SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARM) THERAPY UN IVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2021-05-06 US disclosed
US-10987334-B2 Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2021-04-27 US disclosed
US-10849873-B2 Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy ONCTERNAL THERAPEUTICS, INC (US) 2020-12-01 US disclosed
WO-2020160452-A1 COMBINING SERMS, SARMS, AND CANNABINOIDS FOR IMPROVING SAFETY AND EFFICACY OF ENDOCRINE THERAPIES TESS VENTURES, INC. (US) 2020-08-06 WO disclosed
US-20070161608-A1 Selective androgen receptor modulators for treating muscle wasting UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-07-12 US disclosed
US-20070123563-A1 Selective androgen receptor modulators and method of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-05-31 US disclosed
US-20070123563-A1 Selective androgen receptor modulators and method of use thereof UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-05-31 US disclosed
US-7205437-B2 Selective androgen receptor modulators UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-04-17 US disclosed
US-7205437-B2 Selective androgen receptor modulators UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-04-17 US disclosed
US-20070066568-A1 Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION 2007-03-22 US disclosed
WO-2007027582-A2 TREATING RENAL DISEASE, BURNS, WOUNDS AND SPINAL CORD INJURY WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2007-03-08 WO disclosed
US-20050032750-A1 Treating androgen deficiency in female (ADIF)-associated conditions with SARMS GTX INC 2005-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10987334-B2 Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) AR, CDK6, PGR AR 1/4885
US-20230172897-A1 METHODS OF TREATING BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS AND ADDITIONAL THERAPEUTIC AGENTS AR, CYP19A1, NR5A1 AR 1/4885
US-20070066568-A1 Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators AR, SARM1, OPRM1 AR 1/4885
US-20070123563-A1 Selective androgen receptor modulators and method of use thereof AR, SHBG, ESRRA AR 1/4885
US-20050032750-A1 Treating androgen deficiency in female (ADIF)-associated conditions with SARMS AR, SHBG, CYP19A1 AR 1/4885
US-20070161608-A1 Selective androgen receptor modulators for treating muscle wasting AR, ESRRA, SHBG AR 1/4885
US-20210228529-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING BREAST CANCERS AND METHODS OF USES THEREOF PGR, AR, CDK3 AR 2/4885
US-20210128513-A1 NON-INVASIVE METHOD OF EVALUATING BREAST CANCERS FOR SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARM) THERAPY AR, CYP19A1, GNRHR AR 1/4885
US-10849873-B2 Non-invasive method of evaluating breast cancers for selective androgen receptor modulator (SARM) therapy AR, CYP19A1, GNRHR AR 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.