Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.66 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.66 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.66 |
| ▸ | DRD1 | P21728 | 2/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racepinephrine SCHEMBL28243157 | 0.86 | ADRB2 (0.68) | KDM4EHIF1ATDP1ADRB2TSHR | |
| Metanephrine SCHEMBL29569242 | 0.86 | SLC22A3 (0.73) | KDM4EHIF1ATDP1ADRB2TSHR | |
| Metanephrine SCHEMBL136702 | 0.86 | SLC22A3 (0.73) | KDM4EHIF1ATDP1ADRB2TSHR | |
| SCHEMBL11647079 | 0.86 | KDM4E (0.68) | KDM4EHIF1ATDP1ADRB2TSHR | |
| Metanephrine SCHEMBL30512034 | 0.86 | SLC22A3 (0.73) | KDM4EHIF1ATDP1ADRB2TSHR | |
| Metanephrine SCHEMBL2471378 | 0.84 | SLC22A3 (0.71) | KDM4EHIF1ATDP1ADRB2TSHR | |
| SCHEMBL4847802 | 0.83 | KDM4E (0.64) | KDM4EHIF1ATDP1ADRB2TSHR | |
| SCHEMBL9435060 | 0.83 | KDM4E (0.64) | KDM4EHIF1ATDP1ADRB2TSHR | |
| Metanephrine SCHEMBL2771744 | 0.82 | NFKB1 (0.81) | KDM4EHIF1ATDP1ADRB2TSHR | |
| SCHEMBL344950 | 0.82 | KDM4E (0.62) | KDM4EHIF1ATDP1ADRB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130123253-A1 | MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2013-05-16 | — | — | US | disclosed |
| US-8168635-B2 | 2-(aminomethyl)-5-phenyltetrahydrofuran; 4-(3,4-Dimethoxyphenyl)-2-[5-(2-{5-[2-(5-fluoro-2-methoxyphenyl)-ethyl]-tetrahydrofuran-2-yl}-ethylamino)-pentyl]-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one; dual inhibitor of serotonin reuptake and phosphodiesterase 4 (PDE4) enzyme activity | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090311795-A1 | BILATERAL CONTROL OF FUNCTIONS TRADITIONALLY REGULATED BY ONLY SEROTONIN OR ONLY DOPAMINE | Vidas, Arrett & Steinkraus, P.A. | 2009-12-17 | — | — | US | disclosed |
| WO-2009152426-A1 | BILATERAL CONTROL OF FUNCTIONS TRADITIONALLY REGULATED BY ONLY SEROTONIN OR ONLY DOPAMINE | HINZ MARTIN (US) | 2009-12-17 | — | — | WO | disclosed |
| US-20080261967-A1 | Modulators of Central Nervous System Neurotransmitters | HUMAN BIOMOLECULAR RESEARCH INSTITUTE | 2008-10-23 | — | — | US | disclosed |
| EP-1771435-A4 | MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS | HUMAN BIOMOLECULAR RES INST (US) | 2008-02-13 | — | — | EP | disclosed |
| EP-1771435-A2 | MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS | Human Biomolecular Research Institute (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006025920-A2 | MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2006-03-09 | — | — | WO | disclosed |
| US-4097586-A | Immunochemical assay method | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1978-06-27 | — | — | US | disclosed |
| US-3940475-A | Radioimmune method of assaying quantitatively for a hapten | BIOLOGICAL DEVELOPMENTS, INC. (US) | 1976-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261967-A1 | Modulators of Central Nervous System Neurotransmitters | GAP43, SLC18A2, CHRNA6 | KDM4E 4276/4885HIF1A 3722/4885TDP1 1124/4885 |
| US-20130123253-A1 | MODULATORS OF CENTRAL NERVOUS SYSTEM NEUROTRANSMITTERS | GAP43, SLC18A2, CHRNA6 | KDM4E 4276/4885HIF1A 3722/4885TDP1 1124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.