Metanephrine

Metanephrine

SCHEMBL136702

CNCC(O)c1ccc(O)c(OC)c1

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A3 O75751 1/20 0.73
TSHR P16473 4/20 0.69
CYP3A4 P08684 2/20 0.69
TDP1 Q9NUW8 5/20 0.68
KDM4E B2RXH2 5/20 0.68
MAPT P10636 3/20 0.68
ADRB2 P07550 3/20 0.68
HSD17B10 Q99714 3/20 0.68
HIF1A Q16665 3/20 0.68
MEN1 O00255 2/20 0.68
KMT2A Q03164 2/20 0.68
ADRB1 P08588 2/20 0.68
ADRA2A P08913 2/20 0.68
ADRB3 P13945 2/20 0.68
ADRA2B P18089 2/20 0.68
ADRA2C P18825 2/20 0.68
CYP1A2 P05177 2/20 0.68
ALDH1A1 P00352 2/20 0.68
ADORA3 P0DMS8 1/20 0.68
CYP2D6 P10635 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metanephrine SCHEMBL29569242 1.00 SLC22A3 (0.73) SLC22A3TSHRCYP3A4TDP1KDM4E
Metanephrine SCHEMBL30512034 1.00 SLC22A3 (0.73) SLC22A3TSHRCYP3A4TDP1KDM4E
Metanephrine SCHEMBL2471378 0.98 SLC22A3 (0.71) SLC22A3TSHRCYP3A4TDP1KDM4E
Metanephrine SCHEMBL2771744 0.93 NFKB1 (0.81) SLC22A3TSHRCYP3A4TDP1KDM4E
SCHEMBL11647079 0.87 KDM4E (0.68) SLC22A3TSHRCYP3A4TDP1KDM4E
SCHEMBL29511863 0.87 HIF1A (0.58) SLC22A3TSHRCYP3A4TDP1KDM4E
SCHEMBL3652526 0.87 HIF1A (0.58) SLC22A3TSHRCYP3A4TDP1KDM4E
SCHEMBL18740843 0.86 SLC22A3 (0.56) SLC22A3TSHRCYP3A4TDP1KDM4E
SCHEMBL2691392 0.86 KDM4E (0.66) SLC22A3TSHRCYP3A4TDP1KDM4E
Hydrochloric Acid SCHEMBL3656870 0.85 ADRB2 (0.59) SLC22A3TSHRCYP3A4TDP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1490 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260148848-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2026-05-28 US claimed
EP-4562182-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2025-06-04 EP claimed
WO-2025016307-A1 HEALTH HOMEOSTASIS MODEL, ELASTIC HOMEOSTASIS MODEL, AND USAGE METHOD THEREFOR 汤臣倍健股份有限公司 2025-01-23 WO claimed
CN-118980810-A Method for early diagnosis of motor muscle micro-injury by using saliva metabolite type biomarker 北京理工大学 2024-11-19 CN claimed
US-12117457-B2 Method for simultaneous analysis of neurotransmitters and their metabolites based on derivatization KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2024-10-15 US claimed
US-20240310368-A1 DETECTION KIT FOR CATECHOLAMINES AND METABOLITES THEREOF IN PLASMA/URINE AND DETECTION METHOD THEREOF Calibra Scientific, Inc. (CN) 2024-09-19 US claimed
US-20240047065-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF UNIVERSITY OF DUNDEE (GB) 2024-02-08 US claimed
WO-2024023324-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2024-02-01 WO claimed
EP-4292102-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) 2023-12-20 EP claimed
US-20230323168-A1 CATECHOL MODIFIERS FOR EPOXY ADHESIVES ZYMERGEN INC. 2023-10-12 US claimed
WO-2004080468-A1 IMPROVED BIOAVAILABILITY AND IMPROVED DELIVERY OF ALKALINE PHARMACEUTICAL DRUGS YU RUEY J (US) 2004-09-23 WO claimed
US-20040072187-A1 Novel mammalian receptor genes and uses OREGON HEALTH & SCIENCE UNIVERSITY 2004-04-15 US claimed
EP-1319070-A2 MAMMALIAN RECEPTOR GENES AND USES Oregon Health & Science University (US) 2003-06-18 EP claimed
US-20030078231-A1 Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties WILBURN MICHAEL D (US) 2003-04-24 US claimed
US-20030007961-A1 Orthomolecular vitamin E derivatives WILBURN MICHAEL D (US) 2003-01-09 US claimed
US-20020182600-A1 Method for assaying biological and other constituents using synthetic nucleounits in lateral flow, liquid, and dry chemistry techniques SMITH JACK V (US) 2002-12-05 US claimed
WO-2002022801-A2 MAMMALIAN RECEPTOR GENES AND USES OREGON HEALTH & SCIENCE UNIVERSITY (US) 2002-03-21 WO claimed
US-4591551-A ENZYMATIC TRANSMETHYLATION UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1986-05-27 US claimed
US-4287368-A BY OXIDATION OF METANEPHRINE OR NORMETANEPHRINE WITH A PERIODATE THE UPJOHN COMPANY (US) 1981-09-01 US claimed
US-4108973-A OXIDATION HOFFMANN-LA ROCHE INC. (US) 1978-08-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030078231-A1 Orthomolecular sulpho-adenosylmethionine derivatives with antioxidant properties MAT1A, LPO, TPMT SLC22A3 3686/4885TSHR 3900/4885CYP3A4 2763/4885
US-20030007961-A1 Orthomolecular vitamin E derivatives RBP4, RBP1, VDR SLC22A3 1685/4885TSHR 2780/4885CYP3A4 2879/4885
US-20260148848-A1 BIOMARKERS FOR DIAGNOSIS AND TREATMENT OF ENDOCRINE HYPERTENSION, AND METHODS OF IDENTIFICATION THEREOF SHBG, HSD11B2, HSD11B1 SLC22A3 1104/4885TSHR 1111/4885CYP3A4 3050/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.