Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20186726 | 0.82 | ALDH1A1 (0.45) | POLBTAS1R3TAS1R1TAS1R2TDP1 | |
| SCHEMBL30414393 | 0.82 | KDM5A (0.39) | POLBTAS1R3TAS1R1TAS1R2CYP17A1 | |
| SCHEMBL31015715 | 0.81 | CNR1 (0.38) | POLBCYP17A1TDP1PROKR1PDE4D | |
| SCHEMBL21743152 | 0.81 | NPC1 (0.39) | POLBCA5AKDM4EKMT2APROKR1 | |
| SCHEMBL362611 | 0.79 | CA5A (0.48) | CA5ATDP1KMT2AAHRALDH1A1 | |
| SCHEMBL26918999 | 0.78 | ALOX15 (0.46) | POLBCA5ATDP1KDM4EKMT2A | |
| SCHEMBL15535695 | 0.78 | KMO (0.44) | POLBTAS1R3TAS1R1TAS1R2TDP1 | |
| SCHEMBL23683916 | 0.77 | KMO (0.46) | POLBTAS1R3TAS1R1TAS1R2TDP1 | |
| SCHEMBL15535176 | 0.76 | TDP1 (0.47) | POLBTAS1R3TAS1R1TAS1R2TDP1 | |
| SCHEMBL29998471 | 0.74 | POLB (0.38) | POLBKDM4EGAAPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240300927-A1 | AMIDES AS CBL-B INHIBITORS | GENENTECH, INC. (US) | 2024-09-12 | — | — | US | disclosed |
| EP-4288428-A1 | AMIDES AS CBL-B INHIBITORS | Genentech, Inc. (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022169998-A1 | AMIDES AS CBL-B INHIBITORS | GENENTECH, INC. (US) | 2022-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240300927-A1 | AMIDES AS CBL-B INHIBITORS | CBLB, CBL, CBLC | POLB 1704/4885CA5A 4597/4885TAS1R3 4101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.