Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2691176 | 0.86 | KDM4E (0.70) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Bromide SCHEMBL698678 | 0.85 | KDM4E (0.79) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Bromide SCHEMBL27941533 | 0.85 | KDM4E (0.79) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL4401836 | 0.84 | PABPC1 (0.67) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL765905 | 0.83 | KDM4E (0.76) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Bromide SCHEMBL31501128 | 0.82 | LMNA (0.74) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Iodide SCHEMBL1485891 | 0.82 | PABPC1 (0.70) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Bromide SCHEMBL19468787 | 0.82 | RAB9A (1.00) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Bromide SCHEMBL10921414 | 0.82 | RAB9A (0.70) | RAB9AKMT2AMEN1ALDH1A1KDM4E | |
| Ammonia Solution, Strong SCHEMBL28760030 | 0.81 | KDM4E (0.73) | RAB9AKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858094-B1 | ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE | PIONEER CORP (JP) | 2017-03-08 | — | — | EP | disclosed |
| US-8168307-B2 | Organic compound, charge transport material and organic electroluminescent device | PIONEER CORPORATION (JP) | 2012-05-01 | — | — | US | disclosed |
| US-20090021146-A1 | ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE | PIONEER CORPORATION (JP) | 2009-01-22 | — | — | US | disclosed |
| EP-1858094-A1 | ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE | Pioneer Corporation (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090021146-A1 | ORGANIC COMPOUND, CHARGE TRANSPORT MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE | SLC25A21, SLCO2A1, OCIAD2 | RAB9A 1941/4885KMT2A 1162/4885MEN1 1827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.