Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24304732 | 0.88 | ADORA3 (0.43) | TSHRADORA3ATMSMN1; SMN2MAPT | |
| SCHEMBL29499415 | 0.88 | SMN1; SMN2 (0.36) | TSHRADORA3ATMSMN1; SMN2MAPT | |
| SCHEMBL24305416 | 0.88 | TSHR (0.35) | TSHRADORA3ADORA2AATMSMN1; SMN2 | |
| SCHEMBL24304750 | 0.85 | PKM (0.44) | TSHRSMN1; SMN2MAPTHDAC1POLB | |
| SCHEMBL26980213 | 0.85 | RAB9A (0.45) | TSHRADORA3ATMSMN1; SMN2MAPT | |
| SCHEMBL24305167 | 0.85 | MCHR1 (0.41) | MMP12MMP2MMP13POLBGAA | |
| SCHEMBL29499444 | 0.82 | ADORA3 (0.38) | TSHRADORA3ATMSMN1; SMN2HDAC1 | |
| SCHEMBL24304730 | 0.82 | ADORA2B (0.41) | TSHRADORA3SMN1; SMN2MAPTHDAC1 | |
| SCHEMBL24304729 | 0.82 | TNKS (0.38) | ADORA3HDAC1GAA | |
| SCHEMBL24305162 | 0.81 | TNKS2 (0.38) | TSHRADORA3ATMSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240002416-A1 | MRGPRX4 Agonists and Antagonists | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITAT BONN (DE) | 2024-01-04 | — | — | US | disclosed |
| EP-4229059-A1 | 3-SUBSTITUTED XANTHINE DERIVATIVES AS MRGPRX4 RECEPTOR MODULATORS | Rheinische Friedrich-Wilhelms-Universität Bonn (DE) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022079245-A1 | 3-SUBSTITUTED XANTHINE DERIVATIVES AS MRGPRX4 RECEPTOR MODULATORS | RHEINISCHE-FRIEDRICH-WILHELMS-UNIVERSITÄT BONN (DE) | 2022-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240002416-A1 | MRGPRX4 Agonists and Antagonists | MRGPRX4, MRGPRX1, MRGPRX2 | TSHR 630/4885HCAR2 201/4885ADORA3 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.