Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | RXRB | P28702 | 1/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 4/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2698488 | 1.00 | NR4A1 (0.50) | NR4A1NR4A2NR4A3ALDH1A1CES2 | |
| SCHEMBL25142176 | 0.95 | NR4A1 (0.54) | NR4A1NR4A2NR4A3ALDH1A1CES2 | |
| SCHEMBL2698826 | 0.87 | RXRA (0.45) | NR4A1NR4A2NR4A3ALDH1A1RXRA | |
| SCHEMBL2698824 | 0.87 | RXRA (0.45) | NR4A1NR4A2NR4A3ALDH1A1RXRA | |
| SCHEMBL2697768 | 0.83 | MAPT (0.50) | ALDH1A1CES2CES1RXRARXRB | |
| SCHEMBL2697875 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CES2CES1RXRARXRB | |
| SCHEMBL2700542 | 0.83 | CYP1A2 (0.54) | ALDH1A1CES2CES1RXRARXRB | |
| SCHEMBL2700543 | 0.83 | CYP1A2 (0.54) | ALDH1A1CES2CES1RXRARXRB | |
| SCHEMBL2697879 | 0.83 | ALDH1A1 (0.44) | ALDH1A1CES2CES1RXRARXRB | |
| SCHEMBL2700540 | 0.83 | MAPT (0.50) | ALDH1A1CES2CES1RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580827-B2 | Anti-Francisella agents | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-11-12 | — | — | US | disclosed |
| EP-2246332-B1 | Pyrazole derivatives as anti-francisella agents | UNIV OHIO STATE RES FOUND (US) | 2013-09-18 | — | — | EP | disclosed |
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-01-03 | — | — | US | disclosed |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2012-05-03 | — | — | US | disclosed |
| EP-2246332-A1 | Pyrazole derivatives as anti-francisella agents | The Ohio State University Research Foundation (US) | 2010-11-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130005788-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | NR4A1 3642/4885NR4A2 3704/4885NR4A3 4014/4885 |
| US-20120108823-A1 | ANTI-FRANCISELLA AGENTS | PTGS1, PTGS2, PTGES2 | NR4A1 3642/4885NR4A2 3704/4885NR4A3 4014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.