Sugi Predict

Sugi Predict / Compounds / SCHEMBL26987802

SCHEMBL26987802

SCHEMBL26987802

CN(C)c1ccc2cc[nH]c2c1[N+](=O)[O-]

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 8/20 0.44
▸ ALDH1A1 P00352 7/20 0.36
▸ KDM4E B2RXH2 2/20 0.36
▸ HTT P42858 1/20 0.36
▸ HCAR3 P49019 1/20 0.36
▸ BCHE P06276 2/20 0.35
▸ BRD4 O60885 1/20 0.34
▸ TAF1 P21675 1/20 0.34
▸ BRPF1 P55201 1/20 0.34
▸ CREBBP Q92793 1/20 0.34
▸ CECR2 Q9BXF3 1/20 0.34
▸ BRD9 Q9H8M2 1/20 0.34
▸ TSHR P16473 2/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ PHLPP2 Q6ZVD8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ TNF P01375 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26987243 0.77 TDP1 (0.45) MAPTALDH1A1KDM4EHTTTDP1
SCHEMBL4166359 0.74 MAPT (0.44) MAPTALDH1A1KDM4EHTTHCAR3
SCHEMBL31319692 0.72 TNF (0.53) BCHEBRD4TAF1BRPF1CREBBP
SCHEMBL18131140 0.71 ALDH1A1 (0.42) MAPTALDH1A1BRD4TSHRTDP1
SCHEMBL7659226 0.69 TDP1 (0.47) MAPTALDH1A1KDM4EBRD4TAF1
SCHEMBL29082200 0.67 KDM4E (0.50) MAPTKDM4EBCHEBRD4TAF1
SCHEMBL29507016 0.66 TXNRD1 (0.39) MAPTALDH1A1HTTTSHRTDP1
SCHEMBL8352901 0.66 FBP1 (0.39) MAPTALDH1A1BCHEBRD4TAF1
SCHEMBL26683533 0.66 TXNRD1 (0.39) MAPTALDH1A1HTTTSHRTDP1
SCHEMBL259909 0.65 TDP1 (0.54) MAPTALDH1A1KDM4ETSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4551570-A1 NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF Dong-A ST Co., Ltd. (KR) 2025-05-14 — — EP disclosed
US-12240836-B2 Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof DONG-A ST CO., LTD. (KR) 2025-03-04 — — US disclosed
CN-119403798-A Novel compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof 东亚ST 株式会社 2025-02-07 — — CN disclosed
US-20240025884-A1 COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF DONG-A ST CO., LTD. (KR) 2024-01-25 — — US disclosed
WO-2024009215-A1 NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF DONG-A ST CO., LTD. (KR) 2024-01-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12240836-B2 Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof EIF2AK4, GCN1, GCGR MAPT 2789/4885ALDH1A1 3927/4885KDM4E 4591/4885
US-20240025884-A1 COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF EIF2AK4, GCN1, GCGR MAPT 2789/4885ALDH1A1 3927/4885KDM4E 4591/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.