SCHEMBL2699564

SCHEMBL2699564

O=C1C(NS(=O)(=O)c2ccc(Cl)s2)CCCN1c1ccccc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F10 P00742 9/20 0.59
ALDH1A1 P00352 2/20 0.50
GAA P10253 1/20 0.50
HPGD P15428 1/20 0.50
HTT P42858 1/20 0.50
KMT2A Q03164 1/20 0.50
PSEN1 P49768 3/20 0.48
PSEN2 P49810 3/20 0.48
APH1B Q8WW43 3/20 0.48
NCSTN Q92542 3/20 0.48
APH1A Q96BI3 3/20 0.48
PSENEN Q9NZ42 3/20 0.48
HTR1A P08908 4/20 0.45
HTR7 P34969 4/20 0.45
DRD2 P14416 3/20 0.45
HTR6 P50406 3/20 0.45
MCOLN3 Q8TDD5 1/20 0.43
MMP8 P22894 1/20 0.43
MMP12 P39900 1/20 0.43
MMP13 P45452 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18131025 0.93 F10 (0.53) F10ALDH1A1GAAHPGDHTT
SCHEMBL6712834 0.89 F10 (0.69) F10ALDH1A1GAAHPGDHTT
SCHEMBL4684603 0.85 F10 (0.58) F10ALDH1A1GAAHPGDHTT
SCHEMBL4679637 0.80 F10 (0.56) F10HTR1AHTR7DRD2HTR6
SCHEMBL2699984 0.80 F10 (0.54) F10MCOLN3
SCHEMBL2701106 0.80 MMP2 (0.58) F10HTT
SCHEMBL12996611 0.80 MMP2 (0.58) F10HTT
SCHEMBL6991268 0.80 F10 (0.53) F10HTR1AHTR7DRD2HTR6
SCHEMBL6986018 0.78 F10 (0.68) F10
SCHEMBL6991426 0.76 F10 (0.59) F10HTR1AHTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8569507-B2 N-(2-oxo-1-phenylpiperidin-3-yl)sulfonamides for the identification of biological and pharmacological activity INSTITUT UNIV. DE CIENCIA I TECHNOLOGIA, S.A. (ES) 2013-10-29 US disclosed
US-8569507-B2 N-(2-oxo-1-phenylpiperidin-3-yl)sulfonamides for the identification of biological and pharmacological activity INSTITUT UNIV. DE CIENCIA I TECHNOLOGIA, S.A. (ES) 2013-10-29 US disclosed
US-20120142930-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY AMIRA THERAPEUTICS, S.L. (ES) 2012-06-07 US disclosed
US-20120142930-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY AMIRA THERAPEUTICS, S.L. (ES) 2012-06-07 US disclosed
US-20120142930-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY AMIRA THERAPEUTICS, S.L. (ES) 2012-06-07 US disclosed
US-20120129888-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR DRUG DISCOVERY INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) 2012-05-24 US disclosed
US-20120129888-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR DRUG DISCOVERY INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) 2012-05-24 US disclosed
US-20120122708-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) 2012-05-17 US disclosed
US-20120122708-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) 2012-05-17 US disclosed
US-20120122708-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY INSTITUT UNIV. DE CIENCIA I TECNOLOGIA, S. A. (ES) 2012-05-17 US disclosed
EP-2450349-A1 N-(1-PHENYL-2-OXO-3-PIPERIDYL)SULPHONAMIDE LIBRARIES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY Institut Univ. de Ciència i Tecnologia, S.A. (ES) 2012-05-09 EP disclosed
EP-2445879-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL) SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY Institut Univ. de Ciència i Tecnologia, S.A. (ES) 2012-05-02 EP disclosed
EP-2447251-A1 N-(1-PHENYL-2-OXO-3-PIPERIDYL SULPHONAMIDE LIBRARIES FOR DRUG DISCOVERY Institut Univ. de Ciència i Tecnologia, S.A. (ES) 2012-05-02 EP disclosed
WO-2010150204-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL) SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY INSTITUT UNIV. DE CIÈNCIA I TECNOLOGIA, S.A. (ES) 2010-12-29 WO disclosed
WO-2010149819-A1 N-(1-PHENYL-2-OXO-3-PIPERIDYL SULPHONAMIDE LIBRARIES FOR DRUG DISCOVERY INSTITUT UNIV. DE CIÈNCIA I TECNOLOGIA, S.A. (ES) 2010-12-29 WO disclosed
WO-2010150204-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL) SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY INSTITUT UNIV. DE CIÈNCIA I TECNOLOGIA, S.A. (ES) 2010-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120142930-A1 N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY TPX2, TPST2, AADAC F10 4583/4885ALDH1A1 2600/4885GAA 1326/4885
US-20120122708-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR THE IDENTIFICATION OF BIOLOGICAL AND PHARMACOLOGICAL ACTIVITY AADAC, TPST2, SYNJ2 F10 4336/4885ALDH1A1 2349/4885GAA 1607/4885
US-20120129888-A1 LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR DRUG DISCOVERY TPX2, ANKRD52, NCS1 F10 4606/4885ALDH1A1 3292/4885GAA 2630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.