Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | PLAU | P00749 | 2/20 | 0.66 |
| ▸ | F10 | P00742 | 2/20 | 0.66 |
| ▸ | F2 | P00734 | 1/20 | 0.66 |
| ▸ | PLG | P00747 | 1/20 | 0.66 |
| ▸ | PLAT | P00750 | 1/20 | 0.66 |
| ▸ | KLK1 | P06870 | 1/20 | 0.66 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.66 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.58 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PNLIP | P16233 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7764478 | 0.85 | HPGD (0.74) | SMN1; SMN2KDM4EALDH1A1HTTPLAU | |
| SCHEMBL2119568 | 0.85 | HPGD (0.74) | SMN1; SMN2NPC1ALDH1A1HTTRAB9A | |
| SCHEMBL2703391 | 0.85 | FADS1 (0.67) | SMN1; SMN2NPC1KDM4EALDH1A1HTT | |
| SCHEMBL2702708 | 0.84 | PLAU (0.66) | SMN1; SMN2NPC1KDM4EALDH1A1RAB9A | |
| SCHEMBL6592137 | 0.83 | HPGD (0.53) | SMN1; SMN2NPC1ALDH1A1HTTRAB9A | |
| SCHEMBL21336584 | 0.81 | PNLIP (0.61) | SMN1; SMN2NPC1KDM4EHTTRAB9A | |
| SCHEMBL14340061 | 0.81 | KLKB1 (0.58) | NPC1PLAUF10F2PLAT | |
| SCHEMBL7077100 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1ALDH1A1RAB9APLAU | |
| SCHEMBL10192462 | 0.80 | PLAU (0.67) | SMN1; SMN2NPC1KDM4EALDH1A1HTT | |
| SCHEMBL27778782 | 0.78 | TYK2 (0.55) | SMN1; SMN2NPC1HTTRAB9AP2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058378-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES | ROMARK LABORATORIES L.C. (US) | 2012-05-03 | — | — | WO | disclosed |
| US-20120108592-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES | ROMARK LABORATORIES, L.C. | 2012-05-03 | — | — | US | disclosed |
| US-20120108592-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES | ROMARK LABORATORIES, L.C. | 2012-05-03 | — | — | US | disclosed |
| US-20120108592-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES | ROMARK LABORATORIES, L.C. | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108592-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES | PYGL, GYS2, GLS2 | SMN1; SMN2 3414/4885NPC1 2616/4885KDM4E 3251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.