Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 8/20 | 0.48 |
| ▸ | ADH5 | P11766 | 3/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31346245 | 0.78 | GPR35 (0.52) | GPR35ADH5CASP6MEN1ALDH1A1 | |
| SCHEMBL13806625 | 0.77 | ALDH1A1 (0.66) | TP53MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL27021630 | 0.75 | GPR35 (0.45) | GPR35CASP6TP53MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL5485336 | 0.74 | CASP6 (0.47) | GPR35CASP6MEN1ALDH1A1KMT2A | |
| SCHEMBL27021631 | 0.72 | NPC1 (0.45) | GPR35CASP6TP53MEN1ALDH1A1 | |
| SCHEMBL7252895 | 0.70 | ADH5 (0.46) | ADH5TP53MEN1ALDH1A1KMT2A | |
| SCHEMBL21983536 | 0.68 | ALDH1A1 (0.61) | MEN1ALDH1A1KMT2AL3MBTL1GAA | |
| SCHEMBL18262973 | 0.67 | KDM4E (0.61) | GPR35MEN1ALDH1A1KMT2AGAA | |
| SCHEMBL1777649 | 0.66 | ADH5 (0.75) | ADH5TP53ALDH1A1 | |
| SCHEMBL12332445 | 0.66 | NOTUM (0.63) | ADH5TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | LOXO ONCOLOGY, INC. | 2024-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240018115-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | GPR35 890/4885ADH5 3416/4885CASP6 2787/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.