Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 7/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699401 | 0.86 | MAPT (0.48) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL2032135 | 0.75 | MAPT (0.52) | MAPTKMT2AKCNN4CYP1A2HTT | |
| SCHEMBL3364484 | 0.75 | MAPT (0.52) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL4551817 | 0.75 | CYP1A2 (0.41) | MAPTKMT2ACYP1A2KIF11CHRM2 | |
| SCHEMBL6017231 | 0.74 | KIF11 (0.45) | MAPTKMT2AKCNN4CYP1A2HTT | |
| SCHEMBL19812940 | 0.74 | CYP2C19 (0.44) | MAPTKMT2ACYP1A2KIF11CHRM2 | |
| SCHEMBL14101182 | 0.72 | MAPT (0.47) | MAPTKMT2AKCNN4CYP1A2HTT | |
| SCHEMBL3138017 | 0.71 | MAPT (0.55) | MAPTKMT2AKCNN4CYP1A2HTT | |
| SCHEMBL13946506 | 0.71 | MAPT (0.55) | MAPTKMT2AKCNN4HTTKIF11 | |
| SCHEMBL4030430 | 0.71 | MAPT (0.55) | MAPTKMT2AKCNN4HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168668-B2 | Compounds | ASTRAZENECA AB (SE) | 2012-05-01 | — | — | US | disclosed |
| US-20100286202-A1 | New Compounds | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286202-A1 | New Compounds | REN, PCSK9, FURIN | MAPT 67/4885KMT2A 4014/4885KCNN4 3182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.