SCHEMBL270608

SCHEMBL270608

COc1ccc(C(=O)CC(=O)c2c(C)cc(C(C)(C)C)cc2C)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.73
ALDH1A1 P00352 1/20 0.73
ALOX15 P16050 1/20 0.73
APEX1 P27695 1/20 0.73
MAPK1 P28482 1/20 0.73
RECQL P46063 1/20 0.73
HSD17B10 Q99714 1/20 0.73
TDP1 Q9NUW8 1/20 0.73
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C19 P33261 1/20 0.56
MAPT P10636 2/20 0.54
NPC1 O15118 4/20 0.53
RAB9A P51151 3/20 0.53
KMT2A Q03164 3/20 0.50
MEN1 O00255 2/20 0.50
EPHX2 P34913 1/20 0.50
NR1H4 Q96RI1 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5288853 0.90 LMNA (0.60) LMNAALDH1A1ALOX15APEX1MAPK1
SCHEMBL5159215 0.90 LMNA (0.71) LMNAALDH1A1ALOX15APEX1MAPK1
SCHEMBL8984984 0.86 ALOX15 (0.69) LMNAALDH1A1ALOX15APEX1MAPK1
Avobenzone SCHEMBL1768910 0.85 ALDH1A1 (1.00) LMNAALDH1A1ALOX15APEX1MAPK1
Avobenzone SCHEMBL15650 0.85 ALDH1A1 (1.00) LMNAALDH1A1ALOX15APEX1MAPK1
Avobenzone SCHEMBL16506197 0.83 ALDH1A1 (0.97) LMNAALDH1A1ALOX15APEX1MAPK1
SCHEMBL269013 0.82 LMNA (0.72) LMNAALDH1A1ALOX15APEX1MAPK1
Avobenzone SCHEMBL2526688 0.79 LMNA (0.88) LMNAALDH1A1ALOX15APEX1MAPK1
Avobenzone SCHEMBL2037563 0.79 ALDH1A1 (0.88) LMNAALDH1A1ALOX15APEX1MAPK1
Avobenzone SCHEMBL5680371 0.79 TDP1 (0.88) LMNAALDH1A1ALOX15APEX1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4395733-A1 A PHOTOPROTECTIVE PERSONAL CARE COMPOSITION Unilever IP Holdings B.V. (NL) 2024-07-10 EP claimed
US-20240173235-A1 PERSONAL CARE COMPOSITIONS COMPRISING SILAHYDROCARBONS MOMENTIVE PERFORMANCE MATERIALS INC. 2024-05-30 US claimed
EP-4322915-A1 PERSONAL CARE COMPOSITIONS COMPRISING SILAHYDROCARBONS Momentive Performance Materials Inc. (US) 2024-02-21 EP claimed
WO-2023030963-A1 A PHOTOPROTECTIVE PERSONAL CARE COMPOSITION UNILEVER IP HOLDINGS B.V. (NL) 2023-03-09 WO claimed
US-20220226215-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING A DIBENZOYLMETHANE DERIVATIVE, A MEROCYANINE COMPOUND AND A COMPOUND CAPABLE OF ACCEPTING THE TRIPLET EXCITED LEVEL ENERGY OF THE DIBENZOYLMETHANE COMPOUND L'OREAL (FR) 2022-07-21 US claimed
US-20210106509-A1 A sunscreen composition CONOPCO, INC., D/B/A UNILEVER (US) 2021-04-15 US claimed
US-10952944-B2 Cyclocarboxylic acid containing personal care compositions CONOPCO, INC. (US) 2021-03-23 US claimed
EP-3784355-A1 A SUNSCREEN COMPOSITION Unilever N.V. (NL) 2021-03-03 EP claimed
EP-3357483-B1 SUNSCREEN COSMETIC SHISEIDO CO LTD (JP) 2021-01-27 EP claimed
CN-112004579-A Sunscreen compositions 荷兰联合利华有限公司 2020-11-27 CN claimed
US-5672337-A TOPICAL APPLICATION TO SKIN, HAIR L'OREAL (FR) 1997-09-30 US claimed
EP-0717982-B1 Process for photostabilizing of dibenzoylmethan derivatives of sunscreen agent, the photostable cosmetic sunscreen compositions and their use OREAL (FR) 1997-07-23 EP claimed
EP-0780119-A1 Light screening compositions GIVAUDAN-ROURE (INTERNATIONAL) S.A. (CH) 1997-06-25 EP claimed
EP-0754445-A2 Photostable cosmetic light screening compositions GIVAUDAN-ROURE (INTERNATIONAL) S.A. (CH) 1997-01-22 EP claimed
US-5587150-A Photostable cosmetic screening composition containing a UV-A screening agent and an alkyl β, β-diphenylacrylate or α-cyano-β,β-diphenylacrylate L'OREAL (FR) 1996-12-24 US claimed
EP-0748624-A1 Composition containing a dibenzoylmethane derivative and a nanopigment of titanium dioxide and uses thereof L'OREAL (FR) 1996-12-18 EP claimed
US-5576354-A Photostable cosmetic screening composition containing a UV-A screening agent and an alkyl β, β-diphenylacrylate or α-cyano-β,β-diphenylacrylate L'OREAL (FR) 1996-11-19 US claimed
EP-0717982-A1 Process for photostabilizing of dibenzoylmethan derivatives of sunscreen agent, the photostable cosmetic sunscreen compositions and their use L'OREAL (FR) 1996-06-26 EP claimed
EP-0709080-A1 Photostable cosmetic light screening compositions GIVAUDAN-ROURE (INTERNATIONAL) S.A. (CH) 1996-05-01 EP claimed
EP-0514491-B1 LIGHT-RESISTANT FILTERING COSMETIC COMPOSITION CONTAINING A UV-A FILTER AND AN ALKYL BETA, BETA-DIPHENYLACRYLATE OR AN ALKYL ALPHA-CYANO-BETA, BETA-DIPHENYLACRYLATE OREAL (FR) 1993-11-03 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10952944-B2 Cyclocarboxylic acid containing personal care compositions ERCC1, C1R, COL1A1 LMNA 949/4885ALDH1A1 2037/4885ALOX15 12/4885
US-20220226215-A1 PHOTOPROTECTIVE COMPOSITIONS COMPRISING A DIBENZOYLMETHANE DERIVATIVE, A MEROCYANINE COMPOUND AND A COMPOUND CAPABLE OF ACCEPTING THE TRIPLET EXCITED LEVEL ENERGY OF THE DIBENZOYLMETHANE COMPOUND ERCC5, DDT, ERCC1 LMNA 2955/4885ALDH1A1 815/4885ALOX15 1149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.