Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.31 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454404 | 0.81 | UHRF1 (0.40) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 | |
| SCHEMBL23500825 | 0.79 | UHRF1 (0.39) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 | |
| SCHEMBL11616480 | 0.78 | UHRF1 (0.46) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 | |
| SCHEMBL19794971 | 0.78 | HTT (0.32) | HTTKMT2A | |
| SCHEMBL29411258 | 0.78 | HTT (0.32) | HTTKMT2A | |
| Hydrochloric Acid SCHEMBL2750563 | 0.77 | UHRF1 (0.45) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 | |
| SCHEMBL27067135 | 0.76 | SLC6A2 (0.45) | UHRF1CYP1A2SLC6A2SLC6A4KDM4E | |
| SCHEMBL21222762 | 0.76 | LMNA (0.41) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 | |
| SCHEMBL14917587 | 0.75 | NOS3 (0.47) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 | |
| SCHEMBL317221 | 0.74 | UHRF1 (0.52) | UHRF1CYP1A2CYP2A6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | SCHRÖDINGER, INC. | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | UHRF1 2226/4885CYP1A2 3908/4885CYP2A6 4016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.