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SCHEMBL27075952

SCHEMBL27075952

CC(C)(C)OC(=O)N1Cc2c(Br)cnc(Cl)c2C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 1/20 0.38
▸ UCHL1 P09936 2/20 0.35
▸ HDAC1 Q13547 1/20 0.33
▸ HDAC6 Q9UBN7 1/20 0.33
▸ ROCK2 O75116 1/20 0.33
▸ ELANE P08246 1/20 0.33
▸ NR1H2 P55055 2/20 0.32
▸ NR1H3 Q13133 1/20 0.32
▸ BUB1 O43683 1/20 0.32
▸ USP30 Q70CQ3 2/20 0.31
▸ GPR119 Q8TDV5 1/20 0.31
▸ DDB1 Q16531 1/20 0.31
▸ CRBN Q96SW2 1/20 0.31
▸ MEN1 O00255 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ ESR2 Q92731 1/20 0.30
▸ GABRA1 P14867 2/20 0.30
▸ GABRG2 P18507 2/20 0.30
▸ GABRB3 P28472 2/20 0.30
▸ GABRA5 P31644 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29986081 1.00 POLB (0.38) POLBUCHL1HDAC1HDAC6ROCK2
SCHEMBL23089780 0.90 POLB (0.38) POLBUCHL1HDAC1HDAC6ROCK2
SCHEMBL27075959 0.83 POLB (0.37) POLBHDAC1HDAC6ROCK2ELANE
SCHEMBL23090067 0.82 UCHL1 (0.36) POLBUCHL1HDAC1HDAC6BUB1
SCHEMBL23114725 0.81 POLB (0.38) POLBUCHL1HDAC1HDAC6ROCK2
SCHEMBL27075940 0.81 POLB (0.36) POLBUCHL1HDAC1HDAC6ELANE
SCHEMBL30729409 0.81 POLB (0.36) POLBUCHL1HDAC1HDAC6ELANE
SCHEMBL23089773 0.78 HDAC1 (0.36) POLBUCHL1HDAC1HDAC6NR1H2
SCHEMBL29736458 0.78 HDAC1 (0.36) POLBUCHL1HDAC1HDAC6NR1H2
SCHEMBL22663392 0.78 UCHL1 (0.36) UCHL1HDAC1HDAC6ROCK2NR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12466841-B2 Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists Nimbus Saturn, Inc. (US) 2025-11-11 — — US disclosed
US-12071442-B2 Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists Nimbus Saturn, Inc. (US) 2024-08-27 — — US disclosed
US-20240190895-A1 SUBSTITUTED PYRROLO[3,4-c]PYRIDINES AS HPK1 ANTAGONISTS CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) 2024-06-13 — — US disclosed
EP-4313989-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. (US) 2024-02-07 — — EP disclosed
US-20220363695-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. 2022-11-17 — — US disclosed
WO-2022213062-A1 HPK1 ANTAGONISTS AND USES THEREOF Nimbus Saturn, Inc. (US) 2022-10-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220363695-A1 HPK1 ANTAGONISTS AND USES THEREOF PDXK, HIPK1, PCK1 POLB 3344/4885UCHL1 4480/4885HDAC1 1837/4885
US-12466841-B2 Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists PDXK, HIPK1, HIPK3 POLB 2818/4885UCHL1 4451/4885HDAC1 1032/4885
US-12071442-B2 Substituted pyrrolo[3,4-c]pyridines as HPK1 antagonists PDXK, HIPK1, PGK1 POLB 2964/4885UCHL1 4572/4885HDAC1 1544/4885
US-20240190895-A1 SUBSTITUTED PYRROLO[3,4-c]PYRIDINES AS HPK1 ANTAGONISTS PDXK, HIPK1, HIPK3 POLB 2818/4885UCHL1 4451/4885HDAC1 1032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.