SCHEMBL2708504

SCHEMBL2708504

Nc1cnc2cc(Cl)ccc2c1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 4/20 0.59
SOS2 Q07890 1/20 0.59
CYP3A4 P08684 4/20 0.45
ALDH1A1 P00352 3/20 0.45
TSHR P16473 3/20 0.45
ALOX15 P16050 2/20 0.45
TDP1 Q9NUW8 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
CYP1A2 P05177 2/20 0.41
FERMT2 Q96AC1 1/20 0.41
CYP2D6 P10635 1/20 0.40
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
CCR1 P32246 1/20 0.39
BCHE P06276 1/20 0.39
CHRM1 P11229 1/20 0.39
ACHE P22303 1/20 0.39
EPHX2 P34913 1/20 0.39
PKM P14618 1/20 0.39
CASP1 P29466 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5765299 0.83 NR4A2 (0.58) NR4A2SOS2CYP3A4ALDH1A1TSHR
SCHEMBL22323491 0.81 HTT (0.41) NR4A2SOS2ACHE
SCHEMBL20494859 0.81 NR4A2 (0.56) NR4A2SOS2CYP3A4ALDH1A1TSHR
SCHEMBL10424586 0.81 NR4A2 (0.56) NR4A2SOS2CYP3A4ALDH1A1TSHR
SCHEMBL29392254 0.81 NR4A2 (0.56) NR4A2SOS2CYP3A4ALDH1A1TSHR
SCHEMBL18283403 0.80 ALDH1A1 (0.50) NR4A2SOS2CYP3A4ALDH1A1ALOX15
SCHEMBL6473683 0.78 HPGDS (0.44) CYP3A4ALDH1A1TSHRFERMT2MAPT
SCHEMBL15111074 0.77 NR4A2 (0.46) NR4A2SOS2CYP3A4ALDH1A1ALOX15
SCHEMBL2519868 0.77 ALDH1A1 (0.54) NR4A2SOS2CYP3A4ALDH1A1CYP1A2
SCHEMBL18283388 0.77 NR4A2 (0.46) NR4A2SOS2CYP3A4ALDH1A1ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3366311-B1 HYDRAZINO-1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM 3M INNOVATIVE PROPERTIES CO (US) 2020-02-26 EP disclosed
US-10406142-B2 Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom 3M LNNOVATIVE PROPERTIES COMPANY (US) 2019-09-10 US disclosed
EP-3366311-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM 3M Innovative Properties Co. (US) 2018-08-29 EP disclosed
EP-2718292-B1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM 3M INNOVATIVE PROPERTIES CO (US) 2018-03-14 EP disclosed
US-20170173164-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2017-06-22 US disclosed
US-9585968-B2 Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom 3M INNOVATIVE PROPERTIES COMPANY (US) 2017-03-07 US disclosed
US-20150352218-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM 3M INNOVATIVE PROPERTIES COMPANY 2015-12-10 US disclosed
US-9107958-B2 Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-08-18 US disclosed
US-20140286988-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM 3M INNOVATIVE PROPERTIES COMPANY (US) 2014-09-25 US disclosed
EP-2718292-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM 3M Innovative Properties Company (US) 2014-04-16 EP disclosed
EP-1789042-A4 1-ALKOXY 1H-IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES CO (US) 2009-07-22 EP disclosed
US-20090005376-A1 imidazonaphthyridines, imidazopyridines, imidazoquinolines, and imidazote-trahydroquinolines; immunomodulators for inducing cytokine biosynthesis; for treatment of viral and neoplastic diseases 3M INNOVATIVE PROPERTIES COMPANY 2009-01-01 US disclosed
CN-101312975-A Method for 1h-imidazo[4,5-c]pyridines and analogs thereof COLEY PHARM GROUP INC (US) 2008-11-26 CN disclosed
EP-1937683-A1 METHOD FOR 1H-IMIDAZOÝ4,5-c¨PYRIDINES AND ANALOGS THEREOF Coley Pharmaceutical Group, Inc. (US) 2008-07-02 EP disclosed
US-20070219196-A1 AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2007-09-20 US disclosed
EP-1789042-A2 1-ALKOXY 1H-IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-05-30 EP disclosed
WO-2007035935-A1 METHOD FOR 1H-IMIDAZO[4,5-c]PYRIDINES AND ANALOGS THEREOF COLEY PHARMACEUTICAL GROUP, INC. (US) 2007-03-29 WO disclosed
EP-1730143-A2 AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES 3M Innovative Properties Company (US) 2006-12-13 EP disclosed
WO-2006028962-A2 1-ALKOXY 1H-IMIDAZO RING SYSTEMS AND METHODS 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-03-16 WO disclosed
WO-2005094531-A2 AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-10-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140286988-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM IL15, IL2, HNMT NR4A2 2816/4885SOS2 4201/4885CYP3A4 1978/4885
US-20170173164-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM IL15, IL2, HNMT NR4A2 2816/4885SOS2 4201/4885CYP3A4 1978/4885
US-10406142-B2 Hydrazino 1H-imidazoquinolin-4-amines and conjugates made therefrom IL15, IL2, HNMT NR4A2 2816/4885SOS2 4201/4885CYP3A4 1978/4885
US-20070219196-A1 AMIDE SUBSTITUTED IMIDAZOPYRIDINES, IMIDAZOQUINOLINES, AND IMIDAZONAPHTHYRIDINES IL2, IL4, IFNG NR4A2 391/4885SOS2 4475/4885CYP3A4 814/4885
US-20150352218-A1 HYDRAZINO 1H-IMIDAZOQUINOLIN-4-AMINES AND CONJUGATES MADE THEREFROM IL15, IL2, HNMT NR4A2 2816/4885SOS2 4201/4885CYP3A4 1978/4885
US-20090005376-A1 imidazonaphthyridines, imidazopyridines, imidazoquinolines, and imidazote-trahydroquinolines; immunomodulators for inducing cytokine biosynthesis; for treatment of viral and neoplastic diseases IL2, IL4, IRF3 NR4A2 186/4885SOS2 3394/4885CYP3A4 386/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.