Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | RXRG | P48443 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MDM4 | O15151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23329062 | 0.79 | RAB9A (0.44) | KDM4ETP53MAPTTYRHPGD | |
| SCHEMBL24665780 | 0.75 | NOTUM (0.57) | RXRARXRBRXRGNOTUM | |
| SCHEMBL28586915 | 0.75 | HDAC4 (0.36) | RXRARXRBRXRGMETAP2HDAC4 | |
| SCHEMBL28584793 | 0.75 | HDAC4 (0.36) | RXRARXRBRXRGMETAP2HDAC4 | |
| SCHEMBL28600791 | 0.75 | HDAC4 (0.36) | RXRARXRBRXRGMETAP2PTPN5 | |
| SCHEMBL28578099 | 0.75 | HDAC4 (0.36) | RXRARXRBRXRGMETAP2HDAC4 | |
| SCHEMBL30171029 | 0.74 | IDO1 (0.54) | ALDH1A1TP53MAPTHPGDALOX15 | |
| SCHEMBL1822901 | 0.74 | NOTUM (0.33) | NOTUM | |
| SCHEMBL5020146 | 0.74 | HSD17B1 (0.48) | METAP2ALDH1A1CA2CYP3A4CA5A | |
| SCHEMBL8780977 | 0.74 | NOTUM (0.33) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |