Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.56 |
| ▸ | NAMPT | P43490 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12469032 | 0.80 | KMT2A (0.67) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL6774617 | 0.79 | CHRNB2 (0.71) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL5572106 | 0.77 | GAA (0.44) | ALDH1A1KDM4EKMT2AMCL1HTT | |
| SCHEMBL18132518 | 0.77 | ALDH1A1 (0.72) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL12469174 | 0.76 | SIRT2 (0.61) | ALDH1A1KDM4EMCL1CYP11B2NAMPT | |
| SCHEMBL7100294 | 0.75 | NAMPT (0.68) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL2711034 | 0.75 | HTT (0.50) | ALDH1A1KDM4EMEN1HPGDKMT2A | |
| SCHEMBL31558401 | 0.75 | NPC1 (0.49) | ALDH1A1KDM4EKMT2ATSHRUSP2 | |
| SCHEMBL10222845 | 0.75 | NPC1 (0.49) | ALDH1A1KDM4EKMT2ATSHRUSP2 | |
| SCHEMBL12488669 | 0.74 | MCL1 (1.00) | MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2627324-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | The Board of Trustees of The Leland Stanford Junior University (US) | 2013-08-21 | — | — | EP | disclosed |
| WO-2012051117-A2 | SUBSTITUTED BENZAMIDES AND THEIR USES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-04-19 | — | — | WO | disclosed |