Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714048 | 0.92 | EGFR (0.45) | KDM4EMAPTALDH1A1EGFRKMT2A | |
| SCHEMBL2713052 | 0.82 | MAPT (0.48) | KDM4EMAPTALDH1A1L3MBTL1EGFR | |
| SCHEMBL2712881 | 0.77 | KMT2A (0.47) | KDM4EMAPTALDH1A1EGFRKMT2A | |
| SCHEMBL2714883 | 0.76 | SYK (0.47) | — | |
| SCHEMBL2713091 | 0.75 | EGFR (0.44) | KDM4EMAPTALDH1A1EGFRKMT2A | |
| SCHEMBL2714049 | 0.71 | ROCK2 (0.43) | KDM4EMAPTALDH1A1EGFRKMT2A | |
| SCHEMBL8320871 | 0.68 | ALDH1A1 (0.79) | KDM4EALDH1A1KMT2AACHEGAA | |
| SCHEMBL2692165 | 0.68 | JAK3 (0.64) | KDM4EMAPTALDH1A1EGFRKMT2A | |
| SCHEMBL763646 | 0.67 | SYK (0.71) | PTK2 | |
| SCHEMBL2713612 | 0.66 | MAPK10 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |