Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 4/20 | 0.52 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2714674 | 0.86 | LMNA (0.53) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9496511 | 0.84 | LMNA (1.00) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29421237 | 0.82 | MAPT (0.65) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2714517 | 0.82 | MAPT (0.65) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28824946 | 0.81 | LMNA (0.70) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29898274 | 0.81 | LMNA (0.70) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2714676 | 0.80 | LMNA (0.46) | LMNAGRM4SYKJAK2JAK1 | |
| SCHEMBL2714675 | 0.79 | LMNA (0.45) | LMNAMAPTHTTGRM4SYK | |
| SCHEMBL29421217 | 0.79 | RAB9A (0.73) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL479805 | 0.77 | DHODH (0.76) | LMNAMAPTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |