Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.67 |
| ▸ | AHR | P35869 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898274 | 1.00 | LMNA (0.70) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9496511 | 0.83 | LMNA (1.00) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5083062 | 0.83 | RAB9A (0.72) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28824955 | 0.81 | RAB9A (1.00) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29898269 | 0.81 | RAB9A (1.00) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28824923 | 0.81 | HDAC3 (0.48) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2713370 | 0.81 | LMNA (0.72) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL28824948 | 0.80 | LMNA (0.48) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL29898301 | 0.80 | LMNA (0.48) | LMNAMAPTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL15635771 | 0.78 | DHODH (0.76) | LMNAMAPTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116574053-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-08-11 | — | — | CN | disclosed |
| CN-114989079-B | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114989079-A | RIPK1 kinase target inhibitor and medical application thereof | 中国药科大学 | 2022-09-02 | — | — | CN | disclosed |