Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.53 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22725120 | 0.79 | RXRA (0.48) | RXRAGRIN1GRIN2BKDM4EALDH1A1 | |
| SCHEMBL27147409 | 0.78 | RXRA (0.42) | RXRAGRIN1GRIN2BARCYP17A1 | |
| SCHEMBL18086468 | 0.78 | KDM4E (0.42) | KDM4EALDH1A1HSD17B10SMN1; SMN2KAT6A | |
| SCHEMBL27137469 | 0.77 | RXRA (0.41) | RXRAGRIN1GRIN2BARCYP17A1 | |
| SCHEMBL27142132 | 0.77 | PTGS2 (0.43) | RXRAGRIN1GRIN2BARLOXL2 | |
| SCHEMBL28876225 | 0.76 | BTK (0.41) | RXRAGRIN1GRIN2BAREPHX2 | |
| SCHEMBL15935175 | 0.75 | RXRA (0.46) | RXRAGRIN1GRIN2BARCYP17A1 | |
| SCHEMBL15832232 | 0.74 | AR (0.46) | RXRAGRIN1GRIN2BARKDM4E | |
| SCHEMBL18529036 | 0.73 | PDK2 (0.45) | RXRAGRIN1GRIN2BARKDM4E | |
| SCHEMBL27133083 | 0.73 | ADRB1 (0.46) | KDM4EALDH1A1HSD17B10CYP17A1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |