Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.32 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27136757 | 0.78 | RXRA (0.53) | RXRAGRIN1GRIN2BARCYP17A1 | |
| SCHEMBL27137469 | 0.77 | RXRA (0.41) | RXRAGRIN1GRIN2BARCYP17A1 | |
| SCHEMBL27142132 | 0.77 | PTGS2 (0.43) | RXRAGRIN1GRIN2BARLOXL2 | |
| SCHEMBL27140638 | 0.76 | CA2 (0.37) | NPC1RAB9APARP1 | |
| SCHEMBL28876225 | 0.76 | BTK (0.41) | RXRAGRIN1GRIN2BAREPHX2 | |
| SCHEMBL27152980 | 0.75 | ADRB1 (0.43) | CYP17A1EPHX2GRM4 | |
| SCHEMBL27140103 | 0.71 | CYP11B2 (0.43) | EPHX2GRM4MEN1NPC1RAB9A | |
| SCHEMBL27137578 | 0.71 | GRIN1 (0.38) | RXRAGRIN1GRIN2BARCYP17A1 | |
| Iodide SCHEMBL27213634 | 0.71 | GRIN1 (0.38) | RXRAGRIN1GRIN2BARCYP17A1 | |
| SCHEMBL18529036 | 0.70 | PDK2 (0.45) | RXRAGRIN1GRIN2BARCYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |