Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 8/20 | 0.41 |
| ▸ | CCR4 | P51679 | 2/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 4/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.38 |
| ▸ | CYBB | P04839 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30846492 | 0.83 | PIK3CD (0.39) | PTPN11SLC40A1CCR4GLO1AGTR1 | |
| SCHEMBL27117954 | 0.83 | PIK3CD (0.39) | PTPN11SLC40A1CCR4GLO1AGTR1 | |
| SCHEMBL27133418 | 0.81 | SLC40A1 (0.43) | PTPN11SLC40A1GLO1AGTR1PAX8 | |
| SCHEMBL27143257 | 0.80 | PTPN11 (0.39) | PTPN11SLC40A1CCR4GLO1AGTR1 | |
| SCHEMBL27138912 | 0.80 | ACLY (0.43) | PTPN11SLC40A1CCR4GLO1AGTR1 | |
| SCHEMBL30847917 | 0.79 | SLC40A1 (0.41) | PTPN11SLC40A1GLO1AGTR1PAX8 | |
| SCHEMBL27132412 | 0.79 | SLC40A1 (0.41) | PTPN11SLC40A1GLO1AGTR1PAX8 | |
| SCHEMBL27154324 | 0.79 | HTR6 (0.38) | PTPN11SLC40A1EGFRTDP1ALDH1A1 | |
| SCHEMBL30846193 | 0.79 | GAA (0.55) | PTPN11SLC40A1CCR4GLO1AGTR1 | |
| SCHEMBL27123592 | 0.79 | GAA (0.55) | PTPN11SLC40A1CCR4GLO1AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044730-A1 | PYRAZOLYLSULFONAMIDE COMPOUNDS AND THEIR USE IN THERAPY | HOTSPOT THERAPEUTICS, INC. (US) | 2024-02-29 | — | — | WO | disclosed |