Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30440577 | 0.81 | SRC (0.51) | HTTKCNJ6KCNJ3MKNK1MKNK2 | |
| SCHEMBL19376938 | 0.81 | MKNK1 (0.55) | CYP11B2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL19376930 | 0.80 | CHEK2 (0.44) | HDAC1HDAC6MKNK1MKNK2 | |
| SCHEMBL17675624 | 0.80 | EGLN1 (0.41) | CYP11B2KCNH2ATMPRMT5HDAC1 | |
| SCHEMBL1428296 | 0.79 | ADRA2A (0.47) | HTTADRA2AADRA2BADRA2CHDAC6 | |
| SCHEMBL28508293 | 0.77 | MET (0.50) | CYP11B2KCNH2ATMATRMKNK1 | |
| SCHEMBL30595305 | 0.77 | HTT (0.46) | HTTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL15006455 | 0.77 | HTT (0.46) | HTTADRA2AADRA2BADRA2CALDH1A1 | |
| SCHEMBL25263472 | 0.77 | PRMT5 (0.46) | ADRA2AADRA2BADRA2CPTGS2PRMT5 | |
| SCHEMBL17675606 | 0.77 | ADRB2 (0.41) | KCNH2HDAC1HDAC6RAB9AMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445909-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | Boehringer Ingelheim International GmbH (DE) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010141273-A1 | DERIVATIVES OF 6,7-DIHYDRO-5H-IMIDAZO[1,2-a]IMIDAZOLE-3-CARBOXYLIC ACID AMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-12-09 | — | — | WO | disclosed |