Sugi Predict

Sugi Predict / Compounds / SCHEMBL1428296

SCHEMBL1428296

SCHEMBL1428296

Cc1ccc(CC(N)=O)nc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADRA2A P08913 2/20 0.47
▸ ADRA2B P18089 2/20 0.47
▸ ADRA2C P18825 2/20 0.47
▸ PLAU P00749 1/20 0.47
▸ RAB9A P51151 2/20 0.43
▸ MAPT P10636 1/20 0.43
▸ NOS3 P29474 1/20 0.42
▸ NOS2 P35228 1/20 0.42
▸ ALDH1A1 P00352 2/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ HTT P42858 1/20 0.40
▸ CCR1 P32246 1/20 0.40
▸ CCR5 P51681 1/20 0.40
▸ CCR8 P51685 1/20 0.40
▸ HDAC6 Q9UBN7 1/20 0.40
▸ CA2 P00918 1/20 0.39
▸ KEAP1 Q14145 1/20 0.39
▸ NFE2L2 Q16236 1/20 0.39
▸ DAO P14920 1/20 0.38
▸ ADORA2A P29274 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2434696 0.82 MAPT (0.44) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL7229581 0.82 RAB9A (0.44) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL1851646 0.81 ADRA2A (0.41) ADRA2AADRA2BADRA2CPLAURAB9A
Hydrochloric Acid SCHEMBL265643 0.81 KEAP1 (0.44) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL11881395 0.81 ADRA2A (0.47) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL1852827 0.80 RAB9A (0.43) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL21378678 0.80 AOC3 (0.46) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL14346900 0.79 MAPT (0.42) ADRA2AADRA2BADRA2CPLAURAB9A
Potassium Ion SCHEMBL31201703 0.79 RAB9A (0.42) ADRA2AADRA2BADRA2CPLAURAB9A
SCHEMBL2714933 0.79 GABRA1 (0.42) ADRA2AADRA2BADRA2CRAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11737463-B2 Pyridine and pyrazine compounds BASF SE (DE) 2023-08-29 — — US disclosed
CN-109563043-B Substituted pyridines as inhibitors of DNMT1 葛兰素史密斯克莱知识产权发展有限公司 2022-05-31 — — CN disclosed
US-20210145002-A1 PYRIDINE AND PYRAZINE COMPOUNDS BASF SE (DE) 2021-05-20 — — US disclosed
US-20140364415-A1 PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS PFIZER LIMITED (GB) 2014-12-11 — — US disclosed
EP-2300464-A1 QUINUCLIDINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2011-03-30 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11737463-B2 Pyridine and pyrazine compounds NDUFS5, IL5, NDUFS4 ADRA2A 2930/4885ADRA2B 2641/4885ADRA2C 1607/4885
US-20210145002-A1 PYRIDINE AND PYRAZINE COMPOUNDS NDUFS5, IL5, NDUFS4 ADRA2A 2930/4885ADRA2B 2641/4885ADRA2C 1607/4885
US-20140364415-A1 PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS DMPK, DTYMK, MUSK ADRA2A 1426/4885ADRA2B 1295/4885ADRA2C 1115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.