Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16215527 | 0.80 | CTSK (0.38) | CTSKCTSSAAK1NR1H2KMT2A | |
| SCHEMBL1424364 | 0.77 | CTSK (0.40) | CTSKCTSS | |
| SCHEMBL4974217 | 0.76 | CTSS (0.34) | CTSKCTSS | |
| SCHEMBL4973031 | 0.73 | CTSK (0.41) | CTSKCTSS | |
| SCHEMBL4973036 | 0.73 | CTSK (0.41) | CTSKCTSS | |
| SCHEMBL7468074 | 0.71 | CTSK (0.33) | CTSKHDAC6 | |
| SCHEMBL1782688 | 0.69 | ALOX5 (0.38) | CTSKCTSSNR1H2KMT2AHDAC6 | |
| SCHEMBL9102349 | 0.69 | ANPEP (0.33) | CTSKCTSS | |
| SCHEMBL30453432 | 0.69 | CTSS (0.36) | CTSKCTSSAAK1NR1H2KMT2A | |
| SCHEMBL8269704 | 0.69 | CTSS (0.36) | CTSKCTSSAAK1NR1H2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |