Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | SHBG | P04278 | 1/20 | 0.40 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29665250 | 0.80 | CASP1 (0.54) | CTBP2PKMSHBGMEN1LMNA | |
| SCHEMBL4697641 | 0.80 | CASP1 (0.54) | CTBP2PKMSHBGMEN1LMNA | |
| SCHEMBL4976027 | 0.78 | CES1 (0.44) | MEN1TSHRKMT2AMAPK1 | |
| SCHEMBL1907877 | 0.76 | IDO1 (0.32) | — | |
| SCHEMBL1627494 | 0.75 | CTBP2 (0.59) | NPC1RAB9AKCNJ5KCNJ3CTBP2 | |
| SCHEMBL7696588 | 0.75 | L3MBTL1 (0.45) | NPC1RAB9ACTBP2NLRP3MEN1 | |
| SCHEMBL26196702 | 0.74 | KCNJ5 (0.49) | NPC1RAB9AKCNJ5KCNJ3KCNJ6 | |
| SCHEMBL31065987 | 0.72 | GPR119 (0.33) | — | |
| SCHEMBL8446184 | 0.72 | ALDH1A1 (0.50) | NPC1RAB9AKCNJ5KCNJ3KCNJ6 | |
| SCHEMBL26147436 | 0.71 | NPC1 (0.60) | NPC1RAB9AMEN1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334287-A1 | NLRP3 INFLAMMASOME-INHIBITING COMPOUNDS AND THE USE THEREOF | Università Degli Studi Di Torino (IT) | 2024-03-13 | — | — | EP | disclosed |