SCHEMBL27181385

SCHEMBL27181385

CC(C)CC(NC(=O)C1CC(CNC(=O)C2Cc3ccccc3C2)=NO1)B(O)O

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ PSMB5 P28074 17/20 0.42
▸ PSMB8 P28062 1/20 0.42
▸ MEN1 O00255 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ TDP1 Q9NUW8 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ PSMB1 P20618 3/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ HPGD P15428 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ PSMB2 P49721 1/20 0.35
▸ POLB P06746 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27181382 1.00 PSMB5 (0.42) PSMB5PSMB8MEN1LMNATSHR
SCHEMBL25400906 0.85 PSMB5 (0.46) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25400915 0.85 PSMB5 (0.46) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25400733 0.85 PSMB5 (0.57) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25400738 0.85 PSMB5 (0.57) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25399678 0.84 PSMB5 (0.56) PSMB5PSMB8
SCHEMBL25399672 0.84 PSMB5 (0.56) PSMB5PSMB8
SCHEMBL25401858 0.81 PSMB5 (0.51) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25401854 0.81 PSMB5 (0.51) PSMB5PSMB8PSMB1PSMB2
SCHEMBL25399858 0.81 CASP1 (0.43) PSMB5PSMB8TSHRPSMB1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570675-B2 Boronic acid compounds LG CHEM, LTD. (KR) 2026-03-10 — — US disclosed
US-20240101579-A1 BORONIC ACID COMPOUNDS LG CHEM, LTD. (KR) 2024-03-28 — — US disclosed
EP-4242213-A1 BORONIC ACID COMPOUND Lg Chem, Ltd. (KR) 2023-09-13 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12570675-B2 Boronic acid compounds PSMB6, PSMB3, PSMB2 PSMB5 10/4885PSMB8 5/4885MEN1 800/4885
US-20240101579-A1 BORONIC ACID COMPOUNDS PSMB11, PSMB1, BACH1 PSMB5 7/4885PSMB8 28/4885MEN1 386/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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