SCHEMBL27189010

SCHEMBL27189010

Cn1c(-c2ccc(OCC(F)(F)C(F)(F)F)nc2)nc2cc(Br)c(Br)cc21

nearest known ligand 0.40

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CYP11B1 P15538 3/20 0.37
▸ CYP11B2 P19099 3/20 0.37
▸ MEN1 O00255 3/20 0.36
▸ KMT2A Q03164 3/20 0.36
▸ DGAT1 O75907 4/20 0.35
▸ PTGS1 P23219 1/20 0.34
▸ PTGS2 P35354 1/20 0.34
▸ CA12 O43570 1/20 0.33
▸ CA1 P00915 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ CA9 Q16790 1/20 0.33
▸ CYP1A2 P05177 1/20 0.32
▸ SCN9A Q15858 3/20 0.32
▸ ALOX5AP P20292 1/20 0.32
▸ USP2 O75604 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ NPSR1 Q6W5P4 1/20 0.31
▸ L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24716126 0.82 CYP11B1 (0.38) CYP11B1CYP11B2MEN1KMT2ADGAT1
SCHEMBL25168715 0.73 DGAT1 (0.45) DGAT1
SCHEMBL30278641 0.73 DGAT1 (0.45) DGAT1
SCHEMBL30278642 0.69 ALDH1A1 (0.39) MEN1KMT2ADGAT1PTGS1PTGS2
SCHEMBL23142381 0.69 ALDH1A1 (0.39) MEN1KMT2ADGAT1PTGS1PTGS2
SCHEMBL30060553 0.67 ATM (0.54) CYP11B1CYP11B2MEN1KMT2ACA12
SCHEMBL28395012 0.67 ATM (0.54) CYP11B1CYP11B2MEN1KMT2ACA12
SCHEMBL23142357 0.62 NPC1 (0.53) MEN1KMT2ADGAT1HPGDNPSR1
SCHEMBL10423590 0.61 MEN1 (0.57) CYP11B1CYP11B2MEN1KMT2ACA12
SCHEMBL17896647 0.61 CYP11B2 (0.67) CYP11B1CYP11B2USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240270712-A1 BENZIMIDAZOLE COMPOUND OR SALT THEREOF, CANINE FILARIASIS CONTROL AGENT CONTAINING SAME, AND METHOD OF USE THEREOF NIHON NOHYAKU CO., LTD. (JP) 2024-08-15 — — US disclosed
EP-4349824-A1 BENZIMIDAZOLE COMPOUND OR SALT THEREOF, CANINE FILARIASIS CONTROL AGENT CONTAINING SAME, AND METHOD OF USE THEREOF Nihon Nohyaku Co., Ltd. (JP) 2024-04-10 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240270712-A1 BENZIMIDAZOLE COMPOUND OR SALT THEREOF, CANINE FILARIASIS CONTROL AGENT CONTAINING SAME, AND METHOD OF USE THEREOF NHERF1, IL4I1, ZYX CYP11B1 1336/4885CYP11B2 1291/4885MEN1 4130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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