Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | VCP | P55072 | 3/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720005 | 0.87 | NPC1 (0.39) | HRH4TSHRLMNAVCPALDH1A1 | |
| SCHEMBL2722467 | 0.87 | MLKL (0.43) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL900372 | 0.87 | ALPL (0.41) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL2720358 | 0.86 | HRH4 (0.45) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL2723739 | 0.86 | VCP (0.40) | HRH4VCPHTR3AKMT2A | |
| SCHEMBL2720674 | 0.86 | HRH4 (0.40) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL2722838 | 0.86 | HRH4 (0.40) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL2722093 | 0.86 | KMT2A (0.41) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL899828 | 0.86 | HRH4 (0.42) | HRH4TSHRLMNAVCPHTR3A | |
| SCHEMBL2721609 | 0.84 | HRH4 (0.39) | HRH4TSHRLMNAVCPHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |