Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | VCP | P55072 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722467 | 0.89 | MLKL (0.43) | HRH4VCPALDH1A1POLBHTR3A | |
| SCHEMBL900372 | 0.89 | ALPL (0.41) | HRH4VCPALDH1A1HTR3ALMNA | |
| SCHEMBL2720358 | 0.88 | HRH4 (0.45) | HRH4VCPALDH1A1POLBHTR3A | |
| SCHEMBL899828 | 0.88 | HRH4 (0.42) | HRH4VCPALDH1A1POLBHTR3A | |
| SCHEMBL2722093 | 0.88 | KMT2A (0.41) | HRH4VCPALDH1A1POLBVDR | |
| SCHEMBL2722838 | 0.88 | HRH4 (0.40) | HRH4VCPALDH1A1POLBHTR3A | |
| SCHEMBL2723739 | 0.88 | VCP (0.40) | HRH4VCPDYRK1AHTR3A | |
| SCHEMBL900465 | 0.87 | IDH2 (0.45) | HRH4ALDH1A1PTPN1LMNA | |
| SCHEMBL2720706 | 0.87 | LMNA (0.44) | LMNA | |
| SCHEMBL2720352 | 0.86 | ALDH1A1 (0.44) | HRH4ALDH1A1POLBVDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |