Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.40 |
| ▸ | VCP | P55072 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722467 | 0.90 | MLKL (0.43) | ALPLKMT2ASMN1; SMN2HRH4MLKL | |
| SCHEMBL2720358 | 0.89 | HRH4 (0.45) | ALPLMAPTKMT2ASMN1; SMN2HRH4 | |
| SCHEMBL2720674 | 0.89 | HRH4 (0.40) | HRH4VCPALDH1A1HTR3ALMNA | |
| SCHEMBL2722093 | 0.89 | KMT2A (0.41) | KMT2AHRH4MLKLVCPALDH1A1 | |
| SCHEMBL2722838 | 0.89 | HRH4 (0.40) | ALPLKMT2ASMN1; SMN2HRH4MLKL | |
| SCHEMBL2723739 | 0.89 | VCP (0.40) | ALPLKMT2AHRH4VCPHTR3A | |
| SCHEMBL899828 | 0.89 | HRH4 (0.42) | KMT2ASMN1; SMN2HRH4MLKLVCP | |
| SCHEMBL2722513 | 0.88 | MLKL (0.51) | MAPTKMT2ASMN1; SMN2KDM4EHRH4 | |
| SCHEMBL2720491 | 0.87 | HRH4 (0.39) | MAPTKMT2ASMN1; SMN2HRH4MLKL | |
| SCHEMBL2720352 | 0.87 | ALDH1A1 (0.44) | HTTSMN1; SMN2KDM4EHRH4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3378476-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | Sensorion (FR) | 2018-09-26 | — | — | EP | disclosed |
| US-9688989-B2 | H4 receptor inhibitors for treating tinnitus | SENSORION (FR) | 2017-06-27 | — | — | US | disclosed |
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | disclosed |
| US-20150176010-A1 | H4 RECEPTOR INHIBITORS FOR TREATING TINNITUS | SENSORION (FR) | 2015-06-25 | — | — | US | disclosed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | disclosed |