Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT known ✓ | Q93088 | 5/20 | 0.42 |
| ▸ | GRM8 | O00222 | 2/20 | 0.62 |
| ▸ | GRM6 | O15303 | 2/20 | 0.62 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.62 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.62 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.62 |
| ▸ | GSR | P00390 | 1/20 | 0.62 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.62 |
| ▸ | GRM5 | P41594 | 1/20 | 0.62 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.62 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.62 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.62 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.62 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.62 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.62 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.62 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.62 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL2504670 | 1.00 | GRM8 (0.62) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL8995461 | 0.98 | GRM8 (0.60) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Norvaline SCHEMBL20476465 | 0.84 | SLC1A2 (0.46) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glycinebetaine SCHEMBL272555 | 0.84 | GSR (0.39) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glycinebetaine SCHEMBL20476484 | 0.84 | GABRP (0.64) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL27992050 | 0.83 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL27992051 | 0.83 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glycinebetaine SCHEMBL1646002 | 0.83 | PTGS1 (0.41) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glycinebetaine SCHEMBL1646004 | 0.83 | PTGS1 (0.41) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Aspartic Acid SCHEMBL379368 | 0.82 | CPT2 (0.44) | GRM8GRM6GRM7GRM4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114044852-B | Polymerizable eutectic solvent, conductive elastomer and preparation method of conductive elastomer | 江南大学 | 2022-11-22 | — | — | CN | claimed |
| CN-114044852-A | Polymerizable eutectic solvent, conductive elastomer and preparation method thereof | 江南大学 | 2022-02-15 | — | — | CN | claimed |
| EP-1446090-A2 | COMPOSITIONS CONTAINING ENZYMES STABILIZED WITH CERTAIN OSMO-PROTECTANTS AND METHODS FOR USING SUCH COMPOSITIONS IN PERSONAL CARE | THE PROCTER & GAMBLE COMPANY (US) | 2004-08-18 | — | — | EP | claimed |
| EP-1446096-A1 | TOPICAL COMPOSITIONS CONTAINING ENZYMES STABILISED WITH INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2004-08-18 | — | — | EP | claimed |
| US-20030175232-A1 | Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care | THE PROCTER & GAMBLE COMPANY | 2003-09-18 | — | — | US | claimed |
| US-20030157088-A1 | Compositions containing enzymes stabilized with inhibitors having certain binding properties and methods for using such compositions in personal care | THE PROCTOR & GAMBLE COMPANY | 2003-08-21 | — | — | US | claimed |
| WO-2003041667-A2 | COMPOSITIONS CONTAINING ENZYMES STABILIZED WITH CERTAIN OSMO-PROTECTANTS AND METHODS FOR USING SUCH COMPOSITIONS IN PERSONAL CARE | THE PROCTER & GAMBLE COMPANY (US) | 2003-05-22 | — | — | WO | claimed |
| WO-2003041680-A1 | TOPICAL COMPOSITIONS CONTAINING ENZYMES STABILIZED WITH INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2003-05-22 | — | — | WO | claimed |
| JP-1275516-A | — | — | None | — | — | JP | disclosed |
| CN-118207050-A | Composition for semiconductor processing and processing method | JSR株式会社 | 2024-06-18 | — | — | CN | disclosed |
| US-20240124734-A1 | Aqueous Ink Jet Ink Composition And Ink Jet Recording Method | SEIKO EPSON CORPORATION (JP) | 2024-04-18 | — | — | US | disclosed |
| CN-112569162-B | Synergistic effect of radix Ophiopogonis extract, amino acid derivative and calcium lactate hydrate | 默克专利股份有限公司 | 2024-04-12 | — | — | CN | disclosed |
| CN-117777784-A | Aqueous inkjet ink composition and inkjet recording method | 精工爱普生株式会社 | 2024-03-29 | — | — | CN | disclosed |
| WO-2024009937-A1 | PLANT GROWTH REGULATOR, PLANT GROWTH ACCELERATION METHOD, OR PLANT GROWTH-REGULATING PRODUCT | 株式会社クレハ | 2024-01-11 | — | — | WO | disclosed |
| US-20030175232-A1 | Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care | THE PROCTER & GAMBLE COMPANY | 2003-09-18 | — | — | US | disclosed |
| US-20030157088-A1 | Compositions containing enzymes stabilized with inhibitors having certain binding properties and methods for using such compositions in personal care | THE PROCTOR & GAMBLE COMPANY | 2003-08-21 | — | — | US | disclosed |
| WO-2003041667-A2 | COMPOSITIONS CONTAINING ENZYMES STABILIZED WITH CERTAIN OSMO-PROTECTANTS AND METHODS FOR USING SUCH COMPOSITIONS IN PERSONAL CARE | THE PROCTER & GAMBLE COMPANY (US) | 2003-05-22 | — | — | WO | disclosed |
| WO-2003041680-A1 | TOPICAL COMPOSITIONS CONTAINING ENZYMES STABILIZED WITH INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2003-05-22 | — | — | WO | disclosed |
| JP-2000143486-A | SKIN PREPARATION FOR EXTERNAL USE | LION CORP | 2000-05-23 | — | — | JP | disclosed |
| JP-H01275516-A | DANDRUFF-PREVENTIVE AGENT AND HAIR-COSMETIC | SHISEIDO CO LTD | 1989-11-06 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030175232-A1 | Compositions containing enzymes stabilized with certain osmo-protectants and methods for using such compositions in personal care | TREH, CUTA, LPO | BHMT 2513/4885GRM8 4833/4885GRM6 4677/4885 |
| US-20030157088-A1 | Compositions containing enzymes stabilized with inhibitors having certain binding properties and methods for using such compositions in personal care | CUTA, LCT, TYR | BHMT 2736/4885GRM8 4858/4885GRM6 4832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.