SCHEMBL27220263

SCHEMBL27220263

COc1cc(C=O)ccc1OC(=O)/C=C/c1ccc(Br)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.55
▸ ALDH1A1 P00352 6/20 0.54
▸ TSHR P16473 1/20 0.54
▸ KDM4E B2RXH2 4/20 0.53
▸ SMN1; SMN2 Q16637 4/20 0.53
▸ MMP1 P03956 2/20 0.53
▸ JUN P05412 1/20 0.52
▸ NFKB1 P19838 1/20 0.52
▸ MAPT P10636 3/20 0.51
▸ FDPS P14324 1/20 0.50
▸ CXCL12 P48061 1/20 0.50
▸ HPGD P15428 1/20 0.50
▸ ALOX15 P16050 1/20 0.50
▸ MAPK1 P28482 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ HDAC3 O15379 1/20 0.49
▸ HDAC4 P56524 1/20 0.49
▸ HDAC1 Q13547 1/20 0.49
▸ HDAC7 Q8WUI4 1/20 0.49
▸ HDAC2 Q92769 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27220248 0.88 KMT2A (0.61) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL13231236 0.88 KMT2A (0.56) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL7855955 0.88 KMT2A (0.61) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL7855954 0.88 KMT2A (0.61) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL29823740 0.88 KMT2A (0.61) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL27220272 0.88 ALDH1A1 (0.54) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL27220142 0.87 ABCG2 (0.59) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2
SCHEMBL27220159 0.86 KMT2A (0.52) KMT2AALDH1A1KDM4ESMN1; SMN2MMP1
SCHEMBL27220410 0.86 KMT2A (0.52) KMT2AALDH1A1KDM4ESMN1; SMN2MMP1
SCHEMBL14879574 0.84 EPHX2 (0.68) KMT2AALDH1A1TSHRKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US claimed
US-12637409-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. (US) 2026-05-26 — — US disclosed
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-26 — — US disclosed
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2024-09-12 — — US disclosed
US-11987551-B2 Styryl carboxylate derivatives Renovel Innovations, Inc. 2024-05-21 — — US disclosed
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES Renovel Innovations, Inc. 2022-07-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220234987-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, FABP7 KMT2A 1056/4885ALDH1A1 313/4885TSHR 2198/4885
US-20240300883-A1 STYRYL CARBOXYLATE DERIVATIVES SCD, ACACB, ACACA KMT2A 780/4885ALDH1A1 369/4885TSHR 2607/4885
US-20240317670-A1 STYRYL CARBOXYLATE DERIVATIVES ACACB, ACACA, GPR119 KMT2A 995/4885ALDH1A1 349/4885TSHR 2397/4885
US-12637409-B2 Styryl carboxylate derivatives GPR119, ACACB, ACACA KMT2A 778/4885ALDH1A1 683/4885TSHR 2260/4885
US-11987551-B2 Styryl carboxylate derivatives ACACB, ACACA, FABP7 KMT2A 1056/4885ALDH1A1 313/4885TSHR 2198/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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