Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLKL | Q8NB16 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722513 | 0.87 | MLKL (0.51) | MLKLCYP2D6MAPK1POLBMAPT | |
| SCHEMBL900262 | 0.85 | CHRM2 (0.54) | MLKLCHRM2CHRM1CYP2D6HTR1A | |
| SCHEMBL899887 | 0.84 | MLKL (0.62) | MLKLCHRM2CHRM1CYP2D6HTR1A | |
| SCHEMBL2720358 | 0.84 | HRH4 (0.45) | MLKLCHRM2CHRM1CYP2D6HTR1A | |
| SCHEMBL2719928 | 0.81 | CHRM2 (0.64) | MLKLCHRM2CHRM1CYP2D6HTR1A | |
| SCHEMBL900372 | 0.79 | ALPL (0.41) | MLKLMAPTKDM4EHRH4KMT2A | |
| SCHEMBL900760 | 0.78 | CHRM2 (0.52) | MLKLCHRM2CHRM1CYP2D6HTR1A | |
| Hydrochloric Acid SCHEMBL15227434 | 0.77 | MAPK1 (0.53) | MLKLCHRM2CHRM1CYP2D6HTR1A | |
| SCHEMBL2720360 | 0.77 | DRD3 (0.38) | CHRM2CHRM1CYP2D6HTR1AADRA2A | |
| SCHEMBL2723739 | 0.76 | VCP (0.40) | MAPK1HRH4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | claimed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | claimed |