Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | TTK | P33981 | 5/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 6/20 | 0.42 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021782 | 0.81 | KDR (0.52) | CSNK2A1LRRK2TTKNTRK1MET | |
| SCHEMBL15407730 | 0.76 | MET (0.47) | LRRK2NTRK1METPIM1FGFR1 | |
| SCHEMBL1648452 | 0.72 | MAP2K4 (0.44) | CSNK2A1TTKFGFR1FLT3KDR | |
| SCHEMBL30141523 | 0.71 | SCN9A (0.50) | LRRK2NTRK1METPIM1FGFR1 | |
| SCHEMBL2723270 | 0.70 | MAP2K4 (0.49) | TTKFLT3KDRMAP2K4KIT | |
| SCHEMBL30368355 | 0.69 | KDR (0.49) | CSNK2A1LRRK2NTRK1METFGFR1 | |
| SCHEMBL8877409 | 0.69 | MAP2K4 (0.44) | CSNK2A1TTKNTRK1METPIM1 | |
| SCHEMBL31029238 | 0.68 | KDR (0.41) | CSNK2A1LRRK2NTRK1METFGFR1 | |
| SCHEMBL3655412 | 0.68 | CAMKK2 (0.55) | FLT3CAMKK2 | |
| SCHEMBL16252836 | 0.68 | MAP2K4 (0.43) | LRRK2TTKNTRK1METFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4385980-A1 | INDAZOLES AS INHIBITORS OF NAV1.8 | Grünenthal GmbH (DE) | 2024-06-19 | — | — | EP | disclosed |