Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 12/20 | 0.45 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27264119 | 0.89 | ALOX15 (0.43) | DRD4DRD2ALOX15MAPTTP53 | |
| SCHEMBL27263753 | 0.88 | MAPT (0.44) | MAPTKCNH2HTR1AADRA1AADRA1B | |
| SCHEMBL27263187 | 0.86 | DRD4 (0.48) | DRD4DRD2HTR1AADRA1AADRA1B | |
| SCHEMBL27263082 | 0.85 | DRD4 (0.45) | DRD4DRD2ALOX15MAPTKCNH2 | |
| SCHEMBL27263185 | 0.83 | TRPC5 (0.51) | DRD4DRD2ALOX15MAPTTP53 | |
| SCHEMBL27263072 | 0.83 | BPTF (0.46) | DRD2MAPTTP53HTR1AADRA1A | |
| SCHEMBL27263873 | 0.82 | ADRA1D (0.52) | HTR1AADRA1AADRA1BADRA1D | |
| SCHEMBL9531418 | 0.82 | KCNH2 (0.53) | DRD4DRD2MAPTKCNH2CYP1A2 | |
| SCHEMBL27264122 | 0.81 | DRD4 (0.50) | DRD4DRD2ALOX15MAPTKCNH2 | |
| SCHEMBL27263632 | 0.81 | HTR1A (0.48) | DRD4DRD2ALOX15MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |