Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.50 |
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | HTR7 | P34969 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263864 | 0.88 | MAPT (0.53) | DRD4DRD2HTR7HTR1AADRA2A | |
| SCHEMBL27263872 | 0.83 | DRD2 (0.47) | DRD4DRD2HTR7HTR1AHTR2A | |
| SCHEMBL27263188 | 0.81 | DRD4 (0.45) | DRD4DRD2HTR7HTR1AADRA2A | |
| SCHEMBL27263187 | 0.81 | DRD4 (0.48) | DRD4DRD2HTR1AADRA1AADRA1B | |
| SCHEMBL27264119 | 0.81 | ALOX15 (0.43) | DRD4DRD2HTR7HTR1AADRA2A | |
| SCHEMBL27263185 | 0.81 | TRPC5 (0.51) | DRD4DRD2HTR7HTR1AADRA2A | |
| SCHEMBL27263632 | 0.80 | HTR1A (0.48) | DRD4DRD2HTR1AADRA1AADRA1B | |
| SCHEMBL9527520 | 0.77 | HTR7 (0.55) | DRD2HTR7HTR1AADRA1AADRA1B | |
| SCHEMBL9527896 | 0.76 | HTR1A (0.62) | DRD4DRD2HTR7HTR1AADRA2A | |
| SCHEMBL27263980 | 0.76 | DRD2 (0.54) | DRD4DRD2HTR7HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022565-C | Process for preparing piperazinylalkyl-3(2H)-pyridazinones | CL PHARMA (AT) | 1993-10-27 | — | — | CN | disclosed |
| CN-1043129-A | New piperazinyl alkyl-3 (2H)-pyridazinone, its preparation method and as the application of hypotensive agent | CL PHARMA (AT) | 1990-06-20 | — | — | CN | disclosed |